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Article: Cross-Link-Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications

TitleCross-Link-Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications
Authors
Keywordsexcretion
imaging agents
nanomedicine
nanoparticles
second near-infrared window
Issue Date2020
Citation
Angewandte Chemie - International Edition, 2020, v. 59, n. 46, p. 20552-20560 How to Cite?
AbstractMost NIR-IIb fluorophores are nanoparticle-based probes with long retention (≈1 month or longer) in the body. Here, we applied a novel cross-linked coating to functionalize core/shell lead sulfide/cadmium sulfide quantum dots (PbS/CdS QDs) emitting at ≈1600 nm. The coating was comprised of an amphiphilic polymer followed by three crosslinked amphiphilic polymeric layers (P3 coating), imparting high biocompatibility and >90 % excretion of QDs within 2 weeks of intravenous administration. The P3-QDs were conjugated to an engineered anti-CD8 diabody (Cys-diabody) for in vivo molecular imaging of CD8+ cytotoxic T lymphocytes (CTLs) in response to anti-PD-L1 therapy. Two-plex molecular imaging in combination with down-conversion Er nanoparticles (ErNPs) was performed for real-time in vivo monitoring of PD-L1 positive tumor cells and CTLs with cellular resolution by non-invasive NIR-IIb light sheet microscopy. Imaging of angiogenesis in the tumor microenvironment and of lymph nodes deep in the body with a signal-to-background ratio of up to ≈170 was also achieved using P3-QDs.
Persistent Identifierhttp://hdl.handle.net/10722/325486
ISSN
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorWang, Feifei-
dc.contributor.authorZhong, Yeteng-
dc.contributor.authorSalazar, Felix-
dc.contributor.authorLi, Jiachen-
dc.contributor.authorZhang, Mingxi-
dc.contributor.authorRen, Fuqiang-
dc.contributor.authorWu, Anna M.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-02-27T07:33:42Z-
dc.date.available2023-02-27T07:33:42Z-
dc.date.issued2020-
dc.identifier.citationAngewandte Chemie - International Edition, 2020, v. 59, n. 46, p. 20552-20560-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/325486-
dc.description.abstractMost NIR-IIb fluorophores are nanoparticle-based probes with long retention (≈1 month or longer) in the body. Here, we applied a novel cross-linked coating to functionalize core/shell lead sulfide/cadmium sulfide quantum dots (PbS/CdS QDs) emitting at ≈1600 nm. The coating was comprised of an amphiphilic polymer followed by three crosslinked amphiphilic polymeric layers (P3 coating), imparting high biocompatibility and >90 % excretion of QDs within 2 weeks of intravenous administration. The P3-QDs were conjugated to an engineered anti-CD8 diabody (Cys-diabody) for in vivo molecular imaging of CD8+ cytotoxic T lymphocytes (CTLs) in response to anti-PD-L1 therapy. Two-plex molecular imaging in combination with down-conversion Er nanoparticles (ErNPs) was performed for real-time in vivo monitoring of PD-L1 positive tumor cells and CTLs with cellular resolution by non-invasive NIR-IIb light sheet microscopy. Imaging of angiogenesis in the tumor microenvironment and of lymph nodes deep in the body with a signal-to-background ratio of up to ≈170 was also achieved using P3-QDs.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie - International Edition-
dc.subjectexcretion-
dc.subjectimaging agents-
dc.subjectnanomedicine-
dc.subjectnanoparticles-
dc.subjectsecond near-infrared window-
dc.titleCross-Link-Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.202008083-
dc.identifier.pmid32681553-
dc.identifier.scopuseid_2-s2.0-85090089862-
dc.identifier.volume59-
dc.identifier.issue46-
dc.identifier.spage20552-
dc.identifier.epage20560-
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000566437100001-

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