File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3390/v12050540
- Scopus: eid_2-s2.0-85084790200
- PMID: 32422937
- WOS: WOS:000565860200057
Supplementary
- Citations:
- Appears in Collections:
Article: The phylogeography of MERS-CoV in hospital outbreak-associated cases compared to sporadic cases in Saudi Arabia
Title | The phylogeography of MERS-CoV in hospital outbreak-associated cases compared to sporadic cases in Saudi Arabia |
---|---|
Authors | |
Keywords | Epidemiology Hospital outbreaks MERS-CoV Nosocomial Phylogenetics Phylogeography |
Issue Date | 2020 |
Citation | Viruses, 2020, v. 12, n. 5, article no. v12050540 How to Cite? |
Abstract | This study compared the phylogeography of MERS-CoV between hospital outbreak-associated cases and sporadic cases in Saudi Arabia. We collected complete genome sequences from human samples in Saudi Arabia and data on the multiple risk factors of human MERS-CoV in Saudi Arabia reported from 2012 to 2018. By matching each sequence to human cases, we identified isolates as hospital outbreak-associated cases or sporadic cases. We used Bayesian phylogenetic methods including temporal, discrete trait analysis and phylogeography to uncover transmission routes of MERS-CoV isolates between hospital outbreaks and sporadic cases. Of the 120 sequences collected between 19 June 2012 and 23 January 2017, there were 64 isolates from hospital outbreak-associated cases and 56 from sporadic cases. Overall, MERS-CoV is fast evolving at 7.43 × 10-4 substitutions per site per year. Isolates from hospital outbreaks showed unusually fast evolutionary speed in a shorter time-frame than sporadic cases. Multiple introductions of different MERS-CoV strains occurred in three separate hospital outbreaks. MERS-CoV appears to be mutating in humans. The impact of mutations on viruses transmissibility in humans is unknown. |
Persistent Identifier | http://hdl.handle.net/10722/325475 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Xin | - |
dc.contributor.author | Adam, Dillon Charles | - |
dc.contributor.author | Chughtai, Abrar Ahmad | - |
dc.contributor.author | Stelzer-Braid, Sacha | - |
dc.contributor.author | Scotch, Matthew | - |
dc.contributor.author | MacIntyre, Chandini Raina | - |
dc.date.accessioned | 2023-02-27T07:33:36Z | - |
dc.date.available | 2023-02-27T07:33:36Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Viruses, 2020, v. 12, n. 5, article no. v12050540 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325475 | - |
dc.description.abstract | This study compared the phylogeography of MERS-CoV between hospital outbreak-associated cases and sporadic cases in Saudi Arabia. We collected complete genome sequences from human samples in Saudi Arabia and data on the multiple risk factors of human MERS-CoV in Saudi Arabia reported from 2012 to 2018. By matching each sequence to human cases, we identified isolates as hospital outbreak-associated cases or sporadic cases. We used Bayesian phylogenetic methods including temporal, discrete trait analysis and phylogeography to uncover transmission routes of MERS-CoV isolates between hospital outbreaks and sporadic cases. Of the 120 sequences collected between 19 June 2012 and 23 January 2017, there were 64 isolates from hospital outbreak-associated cases and 56 from sporadic cases. Overall, MERS-CoV is fast evolving at 7.43 × 10-4 substitutions per site per year. Isolates from hospital outbreaks showed unusually fast evolutionary speed in a shorter time-frame than sporadic cases. Multiple introductions of different MERS-CoV strains occurred in three separate hospital outbreaks. MERS-CoV appears to be mutating in humans. The impact of mutations on viruses transmissibility in humans is unknown. | - |
dc.language | eng | - |
dc.relation.ispartof | Viruses | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Epidemiology | - |
dc.subject | Hospital outbreaks | - |
dc.subject | MERS-CoV | - |
dc.subject | Nosocomial | - |
dc.subject | Phylogenetics | - |
dc.subject | Phylogeography | - |
dc.title | The phylogeography of MERS-CoV in hospital outbreak-associated cases compared to sporadic cases in Saudi Arabia | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/v12050540 | - |
dc.identifier.pmid | 32422937 | - |
dc.identifier.pmcid | PMC7290704 | - |
dc.identifier.scopus | eid_2-s2.0-85084790200 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | article no. v12050540 | - |
dc.identifier.epage | article no. v12050540 | - |
dc.identifier.eissn | 1999-4915 | - |
dc.identifier.isi | WOS:000565860200057 | - |