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Article: Developing a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1

TitleDeveloping a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1
Authors
Keywordsmolecular imaging
NIR-II fluorophore
PD-L1
renal excretion
Issue Date2018
Citation
Advanced Functional Materials, 2018, v. 28, n. 50, article no. 1804956 How to Cite?
AbstractFluorescence imaging in the second near-infrared (NIR-II) window holds impressive advantages of enhanced penetration depth and improved signal-to-noise ratio. Bright NIR-II fluorophores with renal excretion ability and low tissue accumulation are favorable for in vivo molecular imaging applications as they can render the target-mediated molecular imaging process easily distinguishable. Here, a probe (anti-PD-L1-BGP6) comprising a fluorophore (IR-BGP6) covalently bonded to the programmed cell death ligand-1 monoclonal antibody (PD-L1 mAb) for molecular imaging of immune checkpoint PD-L1 (a targeting site upregulated in various tumors for cancer imaging) in the NIR-II window is reported. Through molecular optimization, the bright NIR-II fluorophore IR-BGP6 with fast renal excretion (≈91% excretion in general through urine within the first 10 h postinjection) is developed. The conjugate anti-PD-L1-BGP6 succeeds in profiling PD-L1 expression and realizes efficient noninvasive molecular imaging in vivo, achieving a tumor to normal tissue (T/NT) signal ratio as high as ≈9.5. Compared with the NIR-II fluorophore with high nonspecific tissue accumulation, IR-BGP6 derived PD-L1 imaging significantly enhances the molecular imaging performance, serving as a strong tool for potentially studying underlying mechanism of immunotherapy. The work provides rationales to design renal-excreted NIR-II fluorophores and illustrate their advantages for in vivo molecular imaging.
Persistent Identifierhttp://hdl.handle.net/10722/325416
ISSN
2023 Impact Factor: 18.5
2023 SCImago Journal Rankings: 5.496
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, Hao-
dc.contributor.authorMa, Huilong-
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorWang, Fei Fei-
dc.contributor.authorTian, Ye-
dc.contributor.authorMa, Rui-
dc.contributor.authorYang, Qinglai-
dc.contributor.authorHu, Zhubin-
dc.contributor.authorZhu, Tong-
dc.contributor.authorWang, Weizhi-
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorZhang, Mingxi-
dc.contributor.authorZhong, Yeteng-
dc.contributor.authorSun, Haitao-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-02-27T07:33:06Z-
dc.date.available2023-02-27T07:33:06Z-
dc.date.issued2018-
dc.identifier.citationAdvanced Functional Materials, 2018, v. 28, n. 50, article no. 1804956-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/325416-
dc.description.abstractFluorescence imaging in the second near-infrared (NIR-II) window holds impressive advantages of enhanced penetration depth and improved signal-to-noise ratio. Bright NIR-II fluorophores with renal excretion ability and low tissue accumulation are favorable for in vivo molecular imaging applications as they can render the target-mediated molecular imaging process easily distinguishable. Here, a probe (anti-PD-L1-BGP6) comprising a fluorophore (IR-BGP6) covalently bonded to the programmed cell death ligand-1 monoclonal antibody (PD-L1 mAb) for molecular imaging of immune checkpoint PD-L1 (a targeting site upregulated in various tumors for cancer imaging) in the NIR-II window is reported. Through molecular optimization, the bright NIR-II fluorophore IR-BGP6 with fast renal excretion (≈91% excretion in general through urine within the first 10 h postinjection) is developed. The conjugate anti-PD-L1-BGP6 succeeds in profiling PD-L1 expression and realizes efficient noninvasive molecular imaging in vivo, achieving a tumor to normal tissue (T/NT) signal ratio as high as ≈9.5. Compared with the NIR-II fluorophore with high nonspecific tissue accumulation, IR-BGP6 derived PD-L1 imaging significantly enhances the molecular imaging performance, serving as a strong tool for potentially studying underlying mechanism of immunotherapy. The work provides rationales to design renal-excreted NIR-II fluorophores and illustrate their advantages for in vivo molecular imaging.-
dc.languageeng-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectmolecular imaging-
dc.subjectNIR-II fluorophore-
dc.subjectPD-L1-
dc.subjectrenal excretion-
dc.titleDeveloping a Bright NIR-II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD-L1-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adfm.201804956-
dc.identifier.scopuseid_2-s2.0-85055293466-
dc.identifier.volume28-
dc.identifier.issue50-
dc.identifier.spagearticle no. 1804956-
dc.identifier.epagearticle no. 1804956-
dc.identifier.eissn1616-3028-
dc.identifier.isiWOS:000456421000014-

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