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- Publisher Website: 10.1111/irv.12458
- Scopus: eid_2-s2.0-85021256956
- PMID: 28502086
- WOS: WOS:000404379500001
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Article: Does influenza pandemic preparedness and mitigation require gain-of-function research?
Title | Does influenza pandemic preparedness and mitigation require gain-of-function research? |
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Authors | |
Keywords | influenza pandemics public health surveillance |
Issue Date | 2017 |
Citation | Influenza and other Respiratory Viruses, 2017, v. 11, n. 4, p. 306-310 How to Cite? |
Abstract | The risk and benefits of gain-of-function studies on influenza A have been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain-of-function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain-of-function research and argue that the anticipated benefits have yet to materialize while the significant risks remain. |
Persistent Identifier | http://hdl.handle.net/10722/325353 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.485 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Adam, Dillon C. | - |
dc.contributor.author | Magee, Daniel | - |
dc.contributor.author | Bui, Chau M. | - |
dc.contributor.author | Scotch, Matthew | - |
dc.contributor.author | MacIntyre, C. Raina | - |
dc.date.accessioned | 2023-02-27T07:31:48Z | - |
dc.date.available | 2023-02-27T07:31:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Influenza and other Respiratory Viruses, 2017, v. 11, n. 4, p. 306-310 | - |
dc.identifier.issn | 1750-2640 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325353 | - |
dc.description.abstract | The risk and benefits of gain-of-function studies on influenza A have been widely debated since 2012 when the methods to create two respiratory transmissible H5N1 mutant isolates were published. Opponents of gain-of-function studies argue the biosecurity risk is unacceptable, while proponents cite potential uses for pandemic surveillance, preparedness and mitigation. In this commentary, we provide an overview of the background and applications of gain-of-function research and argue that the anticipated benefits have yet to materialize while the significant risks remain. | - |
dc.language | eng | - |
dc.relation.ispartof | Influenza and other Respiratory Viruses | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | influenza | - |
dc.subject | pandemics | - |
dc.subject | public health surveillance | - |
dc.title | Does influenza pandemic preparedness and mitigation require gain-of-function research? | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/irv.12458 | - |
dc.identifier.pmid | 28502086 | - |
dc.identifier.pmcid | PMC5485867 | - |
dc.identifier.scopus | eid_2-s2.0-85021256956 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 306 | - |
dc.identifier.epage | 310 | - |
dc.identifier.eissn | 1750-2659 | - |
dc.identifier.isi | WOS:000404379500001 | - |