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Article: Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease in Hong Kong: A Prospective Territory-Wide 2-Year Follow-Up Study

TitleSubthalamic Nucleus Deep Brain Stimulation for Parkinson Disease in Hong Kong: A Prospective Territory-Wide 2-Year Follow-Up Study
Authors
KeywordsDeep brain stimulation
Quality of life
Subthalamic nucleus
Issue Date2016
Citation
World Neurosurgery, 2016, v. 93, p. 229-236 How to Cite?
AbstractObjective We assessed the effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson disease at the 1-year and 2-year follow-up evaluations. Unified Parkinson's Disease Rating Scale (UPDRS) motor score at “off” medication (“on” DBS) and quality-of-life assessments (39-item Parkinson's Disease Questionnaire [PDQ-39]) were conducted. The percentage of awake “on” time and awake “off” time and levodopa requirement were also assessed. Methods A 2-year prospective study was conducted of 25 consecutive patients from 3 DBS referral centers in Hong Kong. The patients were treated with bilateral stimulation of the STN. Assessments were performed at 1 year and 2 years after DBS and were compared with the baseline. Results The 2-year outcome assessments were completed by 18 patients. The mean UPDRS motor score improvement was 57% in the first year and 45% in the second year. PDQ-39 showed significant improvement in quality of life for 2 consecutive years. The levodopa requirement decreased 63% in the first year and 55.9% in the second year. The awake “on” time was doubled in the first year and sustained in the second year. Awake “off” time was reduced from 28.1% to 5.9% in the first year and returned to 10.6% in the second year. Improvement of UPDRS motor score, reduction in awake “off” time, and decrease of daily levodopa dosage all were main factors correlated with the improvement in PDQ-39 summary index. Conclusions The effects of STN DBS in patients with Parkinson disease in Hong Kong were satisfactory. The results showed that reduction in UPDRS motor score, awake “off”-time, and daily levodopa dosage were the major drivers of overall improvement in PDQ-39.
Persistent Identifierhttp://hdl.handle.net/10722/325321
ISSN
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.654
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Danny T.M.-
dc.contributor.authorZhu, Cannon X.L.-
dc.contributor.authorLau, Claire K.Y.-
dc.contributor.authorPoon, Tak L.-
dc.contributor.authorCheung, Fung C.-
dc.contributor.authorLee, Michael-
dc.contributor.authorTaw, Benedict-
dc.contributor.authorHung, Kwan N.-
dc.contributor.authorChoi, Priscilla-
dc.contributor.authorAuYeung, Mandy-
dc.contributor.authorChan, Germaine-
dc.contributor.authorCheung, Yuk F.-
dc.contributor.authorChan, Anne Y.Y.-
dc.contributor.authorYeung, Jonas H.M.-
dc.contributor.authorMok, Vincent C.T.-
dc.contributor.authorPoon, Wai S.-
dc.date.accessioned2023-02-27T07:31:32Z-
dc.date.available2023-02-27T07:31:32Z-
dc.date.issued2016-
dc.identifier.citationWorld Neurosurgery, 2016, v. 93, p. 229-236-
dc.identifier.issn1878-8750-
dc.identifier.urihttp://hdl.handle.net/10722/325321-
dc.description.abstractObjective We assessed the effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson disease at the 1-year and 2-year follow-up evaluations. Unified Parkinson's Disease Rating Scale (UPDRS) motor score at “off” medication (“on” DBS) and quality-of-life assessments (39-item Parkinson's Disease Questionnaire [PDQ-39]) were conducted. The percentage of awake “on” time and awake “off” time and levodopa requirement were also assessed. Methods A 2-year prospective study was conducted of 25 consecutive patients from 3 DBS referral centers in Hong Kong. The patients were treated with bilateral stimulation of the STN. Assessments were performed at 1 year and 2 years after DBS and were compared with the baseline. Results The 2-year outcome assessments were completed by 18 patients. The mean UPDRS motor score improvement was 57% in the first year and 45% in the second year. PDQ-39 showed significant improvement in quality of life for 2 consecutive years. The levodopa requirement decreased 63% in the first year and 55.9% in the second year. The awake “on” time was doubled in the first year and sustained in the second year. Awake “off” time was reduced from 28.1% to 5.9% in the first year and returned to 10.6% in the second year. Improvement of UPDRS motor score, reduction in awake “off” time, and decrease of daily levodopa dosage all were main factors correlated with the improvement in PDQ-39 summary index. Conclusions The effects of STN DBS in patients with Parkinson disease in Hong Kong were satisfactory. The results showed that reduction in UPDRS motor score, awake “off”-time, and daily levodopa dosage were the major drivers of overall improvement in PDQ-39.-
dc.languageeng-
dc.relation.ispartofWorld Neurosurgery-
dc.subjectDeep brain stimulation-
dc.subjectQuality of life-
dc.subjectSubthalamic nucleus-
dc.titleSubthalamic Nucleus Deep Brain Stimulation for Parkinson Disease in Hong Kong: A Prospective Territory-Wide 2-Year Follow-Up Study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.wneu.2016.06.002-
dc.identifier.pmid27297243-
dc.identifier.scopuseid_2-s2.0-84977654659-
dc.identifier.volume93-
dc.identifier.spage229-
dc.identifier.epage236-
dc.identifier.eissn1878-8769-
dc.identifier.isiWOS:000390352000035-

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