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- Publisher Website: 10.1016/S0304-3940(01)01589-0
- Scopus: eid_2-s2.0-0035937639
- PMID: 11239707
- WOS: WOS:000167505200006
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Article: Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats
Title | Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats |
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Authors | |
Keywords | Aquaporin-4 Blood-brain barrier Brain injuries Brain oedema Rats |
Issue Date | 2001 |
Citation | Neuroscience Letters, 2001, v. 301, n. 1, p. 21-24 How to Cite? |
Abstract | Aquaporin-4 (AQP4) is the most abundant water channel in the rat brain. In this study, the distribution pattern and mRNA expression levels of AQP4 were examined in a severe traumatic brain injury model by immunohistochemistry and reverse transcription-polymerase chain reaction. Oedema formation and blood-brain barrier (BBB) integrity were assessed by wet-dry weight measurements and immunostaining of endogenous IgG respectively. In the oedematous contusional cortex with impaired BBB integrity, negative immunostaining of AQP4 and down-regulation of its mRNA level were identified (P < 0.05) at 1 day post-injury, while in other oedamatous regions of the injured brain where BBB was intact, there was no significant change in the AQP4 expression level. This heterogeneous pattern of AQP4 responses can be interpreted as follows: focal brain injury (such as a contusion) with impaired BBB resulting in vasogenic oedema is associated with reduction of AQP4 expression, whereas, in cytotoxic oedema, associated with diffuse brain injury with intact BBB, changes in AQP4 expression are not significant. This study provides basic information for investigating new treatments for traumatic brain oedema. © 2001 Elsevier Science Ireland Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/325044 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.745 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ke, Changshu | - |
dc.contributor.author | Poon, Wai Sang | - |
dc.contributor.author | Ng, Ho Keung | - |
dc.contributor.author | Pang, Jesse Chung Sean | - |
dc.contributor.author | Chan, Yung | - |
dc.date.accessioned | 2023-02-27T07:29:15Z | - |
dc.date.available | 2023-02-27T07:29:15Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Neuroscience Letters, 2001, v. 301, n. 1, p. 21-24 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/10722/325044 | - |
dc.description.abstract | Aquaporin-4 (AQP4) is the most abundant water channel in the rat brain. In this study, the distribution pattern and mRNA expression levels of AQP4 were examined in a severe traumatic brain injury model by immunohistochemistry and reverse transcription-polymerase chain reaction. Oedema formation and blood-brain barrier (BBB) integrity were assessed by wet-dry weight measurements and immunostaining of endogenous IgG respectively. In the oedematous contusional cortex with impaired BBB integrity, negative immunostaining of AQP4 and down-regulation of its mRNA level were identified (P < 0.05) at 1 day post-injury, while in other oedamatous regions of the injured brain where BBB was intact, there was no significant change in the AQP4 expression level. This heterogeneous pattern of AQP4 responses can be interpreted as follows: focal brain injury (such as a contusion) with impaired BBB resulting in vasogenic oedema is associated with reduction of AQP4 expression, whereas, in cytotoxic oedema, associated with diffuse brain injury with intact BBB, changes in AQP4 expression are not significant. This study provides basic information for investigating new treatments for traumatic brain oedema. © 2001 Elsevier Science Ireland Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Neuroscience Letters | - |
dc.subject | Aquaporin-4 | - |
dc.subject | Blood-brain barrier | - |
dc.subject | Brain injuries | - |
dc.subject | Brain oedema | - |
dc.subject | Rats | - |
dc.title | Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0304-3940(01)01589-0 | - |
dc.identifier.pmid | 11239707 | - |
dc.identifier.scopus | eid_2-s2.0-0035937639 | - |
dc.identifier.volume | 301 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 21 | - |
dc.identifier.epage | 24 | - |
dc.identifier.isi | WOS:000167505200006 | - |