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Article: Tat-SF1: Cofactor for stimulation of transcriptional elongation by HIV-1 Tat

TitleTat-SF1: Cofactor for stimulation of transcriptional elongation by HIV-1 Tat
Authors
Issue Date1996
Citation
Science, 1996, v. 274, n. 5287, p. 605-610 How to Cite?
AbstractTat may stimulate transcriptional elongation by recruitment of a complex containing Tat-SF1 and a kinase to the human immunodeficiency virus-type 1 (HIV-1) promoter through a Tat-TAR interaction. A complementary DNA for the cellular activity, Tat-SF1, has been isolated. This factor is required for Tat trans-activation and is a substrate of an associated cellular kinase. Cotransfection with the complementary DNA for Tat-SF1 specifically modulates Tat activation. Tat-SF1 contains two RNA recognition motifs and a highly acidic carboxyl-terminal half. It is distantly related to EWS and FUS/TLS, members of a family of putative transcription factors with RNA recognition motifs that are associated with sarcomas.
Persistent Identifierhttp://hdl.handle.net/10722/324997
ISSN
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Qiang-
dc.contributor.authorSharp, Phillip A.-
dc.date.accessioned2023-02-27T07:28:52Z-
dc.date.available2023-02-27T07:28:52Z-
dc.date.issued1996-
dc.identifier.citationScience, 1996, v. 274, n. 5287, p. 605-610-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/324997-
dc.description.abstractTat may stimulate transcriptional elongation by recruitment of a complex containing Tat-SF1 and a kinase to the human immunodeficiency virus-type 1 (HIV-1) promoter through a Tat-TAR interaction. A complementary DNA for the cellular activity, Tat-SF1, has been isolated. This factor is required for Tat trans-activation and is a substrate of an associated cellular kinase. Cotransfection with the complementary DNA for Tat-SF1 specifically modulates Tat activation. Tat-SF1 contains two RNA recognition motifs and a highly acidic carboxyl-terminal half. It is distantly related to EWS and FUS/TLS, members of a family of putative transcription factors with RNA recognition motifs that are associated with sarcomas.-
dc.languageeng-
dc.relation.ispartofScience-
dc.titleTat-SF1: Cofactor for stimulation of transcriptional elongation by HIV-1 Tat-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/science.274.5287.605-
dc.identifier.pmid8849451-
dc.identifier.scopuseid_2-s2.0-0029834383-
dc.identifier.volume274-
dc.identifier.issue5287-
dc.identifier.spage605-
dc.identifier.epage610-
dc.identifier.isiWOS:A1996VN91900049-

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