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- Publisher Website: 10.1111/j.1445-2197.1989.tb01492.x
- Scopus: eid_2-s2.0-0024511161
- PMID: 2920003
- WOS: WOS:A1989T628000017
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Article: SECRETION OF ANTIDIURETIC HORMONE IN NEUROSURGICAL PATIENTS: APPROPRIATE OR INAPPROPRIATE?
Title | SECRETION OF ANTIDIURETIC HORMONE IN NEUROSURGICAL PATIENTS: APPROPRIATE OR INAPPROPRIATE? |
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Authors | |
Keywords | antidiuretic hormone blood volume hyponatraemia natriuresis syndrome of inappropriate antidiuretic hormone. |
Issue Date | 1989 |
Citation | Australian and New Zealand Journal of Surgery, 1989, v. 59, n. 2, p. 173-180 How to Cite? |
Abstract | In neurosurgical patients with hyponatraemia (plasma sodium <130 mmol/1) and natriuresis, increased antidiuretic hormone (adh) secretion may be appropriate rather than inappropriate. Ten such patients were studied prospectively to assess circulating adh concentration and body fluid volumes. Compared with a control group, the mean plasma adh level was significantly elevated (0.9 pmol/1 (s.e.m. = 0.2) versus 0.2 pmol/1 (s.e.m. = 0.1)), the total body water was normal (101% (s.e.m. = 3) versus 100% (s.e.m. = 6)), while the blood volume was significantly reduced (89% (s.e.m. = 3) versus 104% (s.e.m. = 5)). The elevated adh level was therefore appropriate to a reduced blood volume. This suggests that, in neurosurgical patients with hyponatraemia, fluid restriction could be dangerous. Serial observations in this small group of patients showed that salt replacement and normal fluid intake resulted in a fall in the elevated adh levels. Copyright © 1989, Wiley Blackwell. All rights reserved |
Persistent Identifier | http://hdl.handle.net/10722/324966 |
ISSN | 2020 SCImago Journal Rankings: 0.111 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Poon, W. S. | - |
dc.contributor.author | Mendelow, A. D. | - |
dc.contributor.author | Davies, D. L. | - |
dc.contributor.author | Watson, W. | - |
dc.contributor.author | Easton, J. | - |
dc.contributor.author | Morton, J. | - |
dc.date.accessioned | 2023-02-27T07:28:37Z | - |
dc.date.available | 2023-02-27T07:28:37Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | Australian and New Zealand Journal of Surgery, 1989, v. 59, n. 2, p. 173-180 | - |
dc.identifier.issn | 0004-8682 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324966 | - |
dc.description.abstract | In neurosurgical patients with hyponatraemia (plasma sodium <130 mmol/1) and natriuresis, increased antidiuretic hormone (adh) secretion may be appropriate rather than inappropriate. Ten such patients were studied prospectively to assess circulating adh concentration and body fluid volumes. Compared with a control group, the mean plasma adh level was significantly elevated (0.9 pmol/1 (s.e.m. = 0.2) versus 0.2 pmol/1 (s.e.m. = 0.1)), the total body water was normal (101% (s.e.m. = 3) versus 100% (s.e.m. = 6)), while the blood volume was significantly reduced (89% (s.e.m. = 3) versus 104% (s.e.m. = 5)). The elevated adh level was therefore appropriate to a reduced blood volume. This suggests that, in neurosurgical patients with hyponatraemia, fluid restriction could be dangerous. Serial observations in this small group of patients showed that salt replacement and normal fluid intake resulted in a fall in the elevated adh levels. Copyright © 1989, Wiley Blackwell. All rights reserved | - |
dc.language | eng | - |
dc.relation.ispartof | Australian and New Zealand Journal of Surgery | - |
dc.subject | antidiuretic hormone | - |
dc.subject | blood volume | - |
dc.subject | hyponatraemia | - |
dc.subject | natriuresis | - |
dc.subject | syndrome of inappropriate antidiuretic hormone. | - |
dc.title | SECRETION OF ANTIDIURETIC HORMONE IN NEUROSURGICAL PATIENTS: APPROPRIATE OR INAPPROPRIATE? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1445-2197.1989.tb01492.x | - |
dc.identifier.pmid | 2920003 | - |
dc.identifier.scopus | eid_2-s2.0-0024511161 | - |
dc.identifier.volume | 59 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 173 | - |
dc.identifier.epage | 180 | - |
dc.identifier.eissn | 1445-2197 | - |
dc.identifier.isi | WOS:A1989T628000017 | - |