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Article: Intracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: A 31P-magnetic resonance spectroscopy study: Clinical article

TitleIntracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: A <sup>31</sup>P-magnetic resonance spectroscopy study: Clinical article
Authors
KeywordsEnergy metabolism
Magnesium
Magnetic resonance spectroscopy
Subarachnoid hemorrhage
Issue Date2010
Citation
Journal of Neurosurgery, 2010, v. 113, n. 4, p. 763-769 How to Cite?
AbstractObject. Disturbance of cerebral phosphorus-containing metabolites occurs in many disease entities and has not been widely studied in patients with subarachnoid hemorrhage (SAH). Pilot studies have indicated that hypermagnesemic treatment may improve outcome in patients with aneurysmal SAH, but the precise mechanism is not known. The authors hypothesized that, by raising intracellular brain free magnesium in aneurysmal SAH, hypermagnesemic treatment would alter the cerebral energy status. Methods. The authors designed the current study to use 31P-MR spectroscopy (MRS) to investigate intracellular brain free magnesium and cerebral phosphorus-containing metabolites in patients with good-grade aneurysmal SAH, both those receiving and not receiving hypermagnesemic therapy. A total of 37 eligible patients and 23 healthy volunteers were recruited. A total of 81 MRS studies were performed. Results. Hypermagnesemic treatment after aneurysmal SAH produced a small (mean difference 0.018 ± 0.007 mM [+ 13.0%]) but significant elevation of intracellular free magnesium during the 1st week. Aneurysmal SAH produced a depressed membrane metabolism with lower phosphodiester/total phosphate. Conclusions. The MRS finding of elevated brain free intracellular magnesium after intravenous magnesium sulfate infusion is novel, and the changes in membrane metabolism provide insight into the metabolic effects of aneurysmal SAH and future pathophysiological studies.
Persistent Identifierhttp://hdl.handle.net/10722/324940
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.173
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, George K.C.-
dc.contributor.authorYeung, David K.W.-
dc.contributor.authorAhuja, Anil T.-
dc.contributor.authorKing, Ann D.-
dc.contributor.authorLam, Christopher W.K.-
dc.contributor.authorChan, Matthew T.V.-
dc.contributor.authorTony, Gin-
dc.contributor.authorPoon, Wai S.-
dc.date.accessioned2023-02-27T07:28:25Z-
dc.date.available2023-02-27T07:28:25Z-
dc.date.issued2010-
dc.identifier.citationJournal of Neurosurgery, 2010, v. 113, n. 4, p. 763-769-
dc.identifier.issn0022-3085-
dc.identifier.urihttp://hdl.handle.net/10722/324940-
dc.description.abstractObject. Disturbance of cerebral phosphorus-containing metabolites occurs in many disease entities and has not been widely studied in patients with subarachnoid hemorrhage (SAH). Pilot studies have indicated that hypermagnesemic treatment may improve outcome in patients with aneurysmal SAH, but the precise mechanism is not known. The authors hypothesized that, by raising intracellular brain free magnesium in aneurysmal SAH, hypermagnesemic treatment would alter the cerebral energy status. Methods. The authors designed the current study to use 31P-MR spectroscopy (MRS) to investigate intracellular brain free magnesium and cerebral phosphorus-containing metabolites in patients with good-grade aneurysmal SAH, both those receiving and not receiving hypermagnesemic therapy. A total of 37 eligible patients and 23 healthy volunteers were recruited. A total of 81 MRS studies were performed. Results. Hypermagnesemic treatment after aneurysmal SAH produced a small (mean difference 0.018 ± 0.007 mM [+ 13.0%]) but significant elevation of intracellular free magnesium during the 1st week. Aneurysmal SAH produced a depressed membrane metabolism with lower phosphodiester/total phosphate. Conclusions. The MRS finding of elevated brain free intracellular magnesium after intravenous magnesium sulfate infusion is novel, and the changes in membrane metabolism provide insight into the metabolic effects of aneurysmal SAH and future pathophysiological studies.-
dc.languageeng-
dc.relation.ispartofJournal of Neurosurgery-
dc.subjectEnergy metabolism-
dc.subjectMagnesium-
dc.subjectMagnetic resonance spectroscopy-
dc.subjectSubarachnoid hemorrhage-
dc.titleIntracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: A <sup>31</sup>P-magnetic resonance spectroscopy study: Clinical article-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3171/2009.10.JNS09915-
dc.identifier.pmid19911890-
dc.identifier.scopuseid_2-s2.0-77957827878-
dc.identifier.volume113-
dc.identifier.issue4-
dc.identifier.spage763-
dc.identifier.epage769-
dc.identifier.eissn1933-0693-
dc.identifier.isiWOS:000282244700017-

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