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Article: Comparison of polysaccharides in articular cartilage regeneration associated with chondrogenic and autophagy-related gene expression

TitleComparison of polysaccharides in articular cartilage regeneration associated with chondrogenic and autophagy-related gene expression
Authors
KeywordsAgarose
Alginate
Cartilage
Gellan gum
Hyaluronic acid
Issue Date2020
Citation
International Journal of Biological Macromolecules, 2020, v. 146, p. 922-930 How to Cite?
AbstractArticular cartilage exhibits reduced self-healing following degeneration. This research evaluated the effects of hydrogels derived from various polysaccharides—gellan gum (GG), alginate, and agarose—on cartilage regeneration compared with that of hyaluronic acid (HA), which is commonly used in cartilage tissue engineering. Chondrocytes were isolated from the articular cartilage of New Zealand White (NZW) rabbits and stimulated with IL-1β followed by incubation with polysaccharides. The expressions of NF-κB and Cox-2 were decreased and those of IκBα, Sox-9, aggrecan, and type II collagen were increased in HA, GG, and Alginate groups. Osteochondral defects in NZW rabbits were treated with intra-articular polysaccharide injections; all except alginate resulted in tissue regeneration. Significant improvements were observed in cartilage regeneration in the GG and agarose groups. These results show that GG and agarose improve cartilage regeneration by suppressing inflammatory mediators and inducing cartilage formation and autophagy-related gene expression, indicating their potential for cartilage tissue engineering.
Persistent Identifierhttp://hdl.handle.net/10722/324112
ISSN
2023 Impact Factor: 7.7
2023 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHeo, Dong Nyoung-
dc.contributor.authorKim, Han Jun-
dc.contributor.authorLee, Donghyun-
dc.contributor.authorKim, Hyosung-
dc.contributor.authorLee, Sang Jin-
dc.contributor.authorLee, Hye Rim-
dc.contributor.authorKwon, Il Keun-
dc.contributor.authorDo, Sun Hee-
dc.date.accessioned2023-01-13T03:01:35Z-
dc.date.available2023-01-13T03:01:35Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Biological Macromolecules, 2020, v. 146, p. 922-930-
dc.identifier.issn0141-8130-
dc.identifier.urihttp://hdl.handle.net/10722/324112-
dc.description.abstractArticular cartilage exhibits reduced self-healing following degeneration. This research evaluated the effects of hydrogels derived from various polysaccharides—gellan gum (GG), alginate, and agarose—on cartilage regeneration compared with that of hyaluronic acid (HA), which is commonly used in cartilage tissue engineering. Chondrocytes were isolated from the articular cartilage of New Zealand White (NZW) rabbits and stimulated with IL-1β followed by incubation with polysaccharides. The expressions of NF-κB and Cox-2 were decreased and those of IκBα, Sox-9, aggrecan, and type II collagen were increased in HA, GG, and Alginate groups. Osteochondral defects in NZW rabbits were treated with intra-articular polysaccharide injections; all except alginate resulted in tissue regeneration. Significant improvements were observed in cartilage regeneration in the GG and agarose groups. These results show that GG and agarose improve cartilage regeneration by suppressing inflammatory mediators and inducing cartilage formation and autophagy-related gene expression, indicating their potential for cartilage tissue engineering.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Biological Macromolecules-
dc.subjectAgarose-
dc.subjectAlginate-
dc.subjectCartilage-
dc.subjectGellan gum-
dc.subjectHyaluronic acid-
dc.titleComparison of polysaccharides in articular cartilage regeneration associated with chondrogenic and autophagy-related gene expression-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijbiomac.2019.09.215-
dc.identifier.pmid31726172-
dc.identifier.scopuseid_2-s2.0-85075892753-
dc.identifier.volume146-
dc.identifier.spage922-
dc.identifier.epage930-
dc.identifier.eissn1879-0003-
dc.identifier.isiWOS:000516881000095-

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