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Article: Piloting a partially self-financed mode of human immunodeficiency virus pre-exposure prophylaxis delivery for men who have sex with men in hong kong

TitlePiloting a partially self-financed mode of human immunodeficiency virus pre-exposure prophylaxis delivery for men who have sex with men in hong kong
Authors
Issue Date2019
Citation
Hong Kong Medical Journal, 2019, v. 25, n. 5, p. 382-391 How to Cite?
AbstractIntroduction: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) 300 mg/ emtricitabine (FTC) 200 mg is a proven strategy for preventing human immunodeficiency virus (HIV) transmission in men who have sex with men (MSM). This study aimed to test the feasibility and acceptability of PrEP delivered at a pilot clinic for MSM in Hong Kong, where PrEP service is currently unavailable. Methods: Partially self-financed PrEP was provided to HIV-negative adult MSM with high behavioural risk of HIV transmission after excluding hepatitis B infection and renal insufficiency. Participants received daily TDF/FTC for 30 weeks at 13.3% of the drug cost. Adherence and behaviours were monitored through questionnaires while creatinine and HIV/ STI (sexually transmitted infection) incidence were monitored with point-of-care and laboratory tests. Preference for continuing with PrEP was evaluated at the end of the prescription period. Results: Seventy-one PrEP-naïve MSM were included in the study, of whom 57 (80%) were retained at the end of 28 weeks. Satisfactory adherence and self-limiting adverse events were reported, while none of the participants contracted HIV. Risk compensation was observed, with an STI incidence of 3.17 per 100 person-years. At the end of the prescription period, a majority (89%) indicated interest in continuing with PrEP. Preference for PrEP was associated with age ≥28 years and peer influence (P=0.04), while stigma was a concern. Price was a deterrent to self-financed PrEP, and only half (51%) considered a monthly cost of ≤HK$500 (US$1=HK$7.8) as reasonable. Conclusions: A partially self-financed mode of PrEP delivery is feasible with good retention in MSM in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/324108
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, S. S.-
dc.contributor.authorKwan, T. H.-
dc.contributor.authorWong, N. S.-
dc.contributor.authorLee, K. C.K.-
dc.contributor.authorChan, D. P.C.-
dc.contributor.authorLam, T. T.N.-
dc.contributor.authorLui, G. C.Y.-
dc.date.accessioned2023-01-13T03:01:33Z-
dc.date.available2023-01-13T03:01:33Z-
dc.date.issued2019-
dc.identifier.citationHong Kong Medical Journal, 2019, v. 25, n. 5, p. 382-391-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/324108-
dc.description.abstractIntroduction: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) 300 mg/ emtricitabine (FTC) 200 mg is a proven strategy for preventing human immunodeficiency virus (HIV) transmission in men who have sex with men (MSM). This study aimed to test the feasibility and acceptability of PrEP delivered at a pilot clinic for MSM in Hong Kong, where PrEP service is currently unavailable. Methods: Partially self-financed PrEP was provided to HIV-negative adult MSM with high behavioural risk of HIV transmission after excluding hepatitis B infection and renal insufficiency. Participants received daily TDF/FTC for 30 weeks at 13.3% of the drug cost. Adherence and behaviours were monitored through questionnaires while creatinine and HIV/ STI (sexually transmitted infection) incidence were monitored with point-of-care and laboratory tests. Preference for continuing with PrEP was evaluated at the end of the prescription period. Results: Seventy-one PrEP-naïve MSM were included in the study, of whom 57 (80%) were retained at the end of 28 weeks. Satisfactory adherence and self-limiting adverse events were reported, while none of the participants contracted HIV. Risk compensation was observed, with an STI incidence of 3.17 per 100 person-years. At the end of the prescription period, a majority (89%) indicated interest in continuing with PrEP. Preference for PrEP was associated with age ≥28 years and peer influence (P=0.04), while stigma was a concern. Price was a deterrent to self-financed PrEP, and only half (51%) considered a monthly cost of ≤HK$500 (US$1=HK$7.8) as reasonable. Conclusions: A partially self-financed mode of PrEP delivery is feasible with good retention in MSM in Hong Kong.-
dc.languageeng-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePiloting a partially self-financed mode of human immunodeficiency virus pre-exposure prophylaxis delivery for men who have sex with men in hong kong-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.12809/hkmj198030-
dc.identifier.pmid31619578-
dc.identifier.scopuseid_2-s2.0-85074578879-
dc.identifier.volume25-
dc.identifier.issue5-
dc.identifier.spage382-
dc.identifier.epage391-
dc.identifier.isiWOS:000502279200007-

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