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- Publisher Website: 10.1016/j.ijbiomac.2017.08.125
- Scopus: eid_2-s2.0-85029549748
- PMID: 28851638
- WOS: WOS:000417661600135
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Article: Ultrasound-triggered PLGA microparticle destruction and degradation for controlled delivery of local cytotoxicity and drug release
Title | Ultrasound-triggered PLGA microparticle destruction and degradation for controlled delivery of local cytotoxicity and drug release |
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Authors | |
Keywords | Doxorubicin release Microparticle PLGA Ultrasound |
Issue Date | 2018 |
Citation | International Journal of Biological Macromolecules, 2018, v. 106, p. 1211-1217 How to Cite? |
Abstract | In this study, we investigated the low intensity ultrasound (US)-controlled delivery of local cytotoxicity and drug release via induced destruction and degradation of microparticles (MPs) made of poly(lactic-co-glycolic acid) (PLGA). This study was conducted in vitro with potential application towards tumor treatment in conjunction with direct injection. MPs, either loaded with or without doxorubicin (DOX), were prepared using a double-emulsion solvent-evaporation technique. First, the MPs were exposed to US with duty cycle (DC)-modulation. The destruction and degradation of MPs were evaluated using light and scanning electron microscopy. Second, the effects of US-mediated destruction/degradation of MPs on the local cytotoxicity as well as DOX release were evaluated. US-triggered MP destruction/degradation significantly enhanced nearby cell death and DOX release. These affects occurred in proportion to the DC. Our findings indicate that controlled cytotoxicity and DOX release by US could be useful in developing the minimally invasive therapeutic applications for tumor treatment. |
Persistent Identifier | http://hdl.handle.net/10722/324025 |
ISSN | 2023 Impact Factor: 7.7 2023 SCImago Journal Rankings: 1.245 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jang, Kee W. | - |
dc.contributor.author | Seol, Dongrim | - |
dc.contributor.author | Ding, Lei | - |
dc.contributor.author | Heo, Dong Nyoung | - |
dc.contributor.author | Lee, Sang Jin | - |
dc.contributor.author | Martin, James A. | - |
dc.contributor.author | Kwon, Il Keun | - |
dc.date.accessioned | 2023-01-13T03:00:58Z | - |
dc.date.available | 2023-01-13T03:00:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | International Journal of Biological Macromolecules, 2018, v. 106, p. 1211-1217 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.uri | http://hdl.handle.net/10722/324025 | - |
dc.description.abstract | In this study, we investigated the low intensity ultrasound (US)-controlled delivery of local cytotoxicity and drug release via induced destruction and degradation of microparticles (MPs) made of poly(lactic-co-glycolic acid) (PLGA). This study was conducted in vitro with potential application towards tumor treatment in conjunction with direct injection. MPs, either loaded with or without doxorubicin (DOX), were prepared using a double-emulsion solvent-evaporation technique. First, the MPs were exposed to US with duty cycle (DC)-modulation. The destruction and degradation of MPs were evaluated using light and scanning electron microscopy. Second, the effects of US-mediated destruction/degradation of MPs on the local cytotoxicity as well as DOX release were evaluated. US-triggered MP destruction/degradation significantly enhanced nearby cell death and DOX release. These affects occurred in proportion to the DC. Our findings indicate that controlled cytotoxicity and DOX release by US could be useful in developing the minimally invasive therapeutic applications for tumor treatment. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Biological Macromolecules | - |
dc.subject | Doxorubicin release | - |
dc.subject | Microparticle | - |
dc.subject | PLGA | - |
dc.subject | Ultrasound | - |
dc.title | Ultrasound-triggered PLGA microparticle destruction and degradation for controlled delivery of local cytotoxicity and drug release | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2017.08.125 | - |
dc.identifier.pmid | 28851638 | - |
dc.identifier.scopus | eid_2-s2.0-85029549748 | - |
dc.identifier.volume | 106 | - |
dc.identifier.spage | 1211 | - |
dc.identifier.epage | 1217 | - |
dc.identifier.eissn | 1879-0003 | - |
dc.identifier.isi | WOS:000417661600135 | - |