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Article: Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration

TitleDevelopment of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration
Authors
Keywordsbone tissue regeneration
growth factor
heparin
hyaluronic acid
hydrogel
photopolymerization
Issue Date2016
Citation
Macromolecular Research, 2016, v. 24, n. 9, p. 829-837 How to Cite?
AbstractIn this study, the effect of novel BMP-2-loaded photo-cured hydrogels on in vitro and in vivo osteogenesis were explored. The well-defined HA-heparin hydrogel was prepared by a photopolymerization of aminoethyl methacrylate (AEMA) grafted hyaluronic acid (HA) and AEMA-grafted heparin. Subsequently, the resulting hydrogels contained BMP-2 at different concentrations. First, a series of BMP-2-loaded hydrogels were characterized to determine their mechanical properties and release profiles. The results from rheology, swelling ratio, and release kinetics suggest that BMP-2 contained HA-g-Hhep gel (B/HA-g-Hhep gel) had sustained release during 4 weeks with minimal initial burst. Furthermore, the released BMP-2 maintained its biological activity. MTT and live/dead assays showed that the B/HA-g-Hhep gel had good biocompatibility to be used as a scaffold for bone regeneration. In vivo studies of B/HA-g-Hhep gel exhibited significantly enhanced osteogenesis, compared with other types of HA-heparin hydrogels. These excellent results indicated that B/HA-g-Hhep gel has a great potential for a controlled release of growth factor, leading to a good bone regeneration.[Figure not available: see fulltext.]
Persistent Identifierhttp://hdl.handle.net/10722/323984
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.477
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBae, Min Soo-
dc.contributor.authorKo, Na Re-
dc.contributor.authorLee, Sang Jin-
dc.contributor.authorLee, Jung Bok-
dc.contributor.authorHeo, Dong Nyoung-
dc.contributor.authorByun, Wook-
dc.contributor.authorChoi, Byung Joon-
dc.contributor.authorJeon, Hoon Bong-
dc.contributor.authorJang, Hee Jae-
dc.contributor.authorAhn, Ji Yoon-
dc.contributor.authorHwang, Deok Sang-
dc.contributor.authorJung, Bock Young-
dc.contributor.authorKwon, Il Keun-
dc.date.accessioned2023-01-13T03:00:42Z-
dc.date.available2023-01-13T03:00:42Z-
dc.date.issued2016-
dc.identifier.citationMacromolecular Research, 2016, v. 24, n. 9, p. 829-837-
dc.identifier.issn1598-5032-
dc.identifier.urihttp://hdl.handle.net/10722/323984-
dc.description.abstractIn this study, the effect of novel BMP-2-loaded photo-cured hydrogels on in vitro and in vivo osteogenesis were explored. The well-defined HA-heparin hydrogel was prepared by a photopolymerization of aminoethyl methacrylate (AEMA) grafted hyaluronic acid (HA) and AEMA-grafted heparin. Subsequently, the resulting hydrogels contained BMP-2 at different concentrations. First, a series of BMP-2-loaded hydrogels were characterized to determine their mechanical properties and release profiles. The results from rheology, swelling ratio, and release kinetics suggest that BMP-2 contained HA-g-Hhep gel (B/HA-g-Hhep gel) had sustained release during 4 weeks with minimal initial burst. Furthermore, the released BMP-2 maintained its biological activity. MTT and live/dead assays showed that the B/HA-g-Hhep gel had good biocompatibility to be used as a scaffold for bone regeneration. In vivo studies of B/HA-g-Hhep gel exhibited significantly enhanced osteogenesis, compared with other types of HA-heparin hydrogels. These excellent results indicated that B/HA-g-Hhep gel has a great potential for a controlled release of growth factor, leading to a good bone regeneration.[Figure not available: see fulltext.]-
dc.languageeng-
dc.relation.ispartofMacromolecular Research-
dc.subjectbone tissue regeneration-
dc.subjectgrowth factor-
dc.subjectheparin-
dc.subjecthyaluronic acid-
dc.subjecthydrogel-
dc.subjectphotopolymerization-
dc.titleDevelopment of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s13233-016-4112-7-
dc.identifier.scopuseid_2-s2.0-84981543689-
dc.identifier.volume24-
dc.identifier.issue9-
dc.identifier.spage829-
dc.identifier.epage837-
dc.identifier.eissn2092-7673-
dc.identifier.isiWOS:000384600300011-

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