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Article: Generation of functionalized polymer nanolayer on implant surface via initiated chemical vapor deposition (iCVD)

TitleGeneration of functionalized polymer nanolayer on implant surface via initiated chemical vapor deposition (iCVD)
Authors
KeywordsFunctional polymer
Implant
Initiated chemical vapor deposition
Surface treatment
Issue Date2015
Citation
Journal of Colloid and Interface Science, 2015, v. 439, p. 34-41 How to Cite?
AbstractInitiated chemical vapor deposition (iCVD) was utilized to generate a 200. nm thick, uniform, functionalized polymer nanolayer comprised of glycidyl methacrylate (GMA) on the surface of titanium implants as a means to improve cellular attachment. Dot-patterned GMA-coated specimens were prepared as well as fully coated specimens. In vitro cellular responses, including cell morphology, protein adsorption, cell proliferation assays, alkaline phosphate activity (ALP) assays, and calcium deposition assays were studied using adipose derived stem cells. The mechanical stability of the thin film was investigated by XPS and FE-SEM analysis of the GMA-coated implant after implantation to an extracted bone from a pig. The GMA-coated specimens displayed increased protein adsorption, higher alkaline phosphatase activities, and higher calcium deposition as compared to control sample with no cytotoxicity. Additionally, no defect was observed in the test of mechanical stability. Notably, dot-patterned GMA-coated samples displayed higher alkaline phosphatase activities than others. Functionalized polymer nanolayer deposition via iCVD is a flexible and robust technique capable of mass production of biocompatible layers. These properties make this technique very suitable for implant applications in a variety of ways.
Persistent Identifierhttp://hdl.handle.net/10722/323923
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 1.760
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPark, Se Woong-
dc.contributor.authorLee, Donghyun-
dc.contributor.authorLee, Hak Rae-
dc.contributor.authorMoon, Ho Jin-
dc.contributor.authorLee, Bo Ra-
dc.contributor.authorKo, Wan Kyu-
dc.contributor.authorSong, Su Jin-
dc.contributor.authorLee, Sang Jin-
dc.contributor.authorShin, Kwanwoo-
dc.contributor.authorJang, Wonhyeong-
dc.contributor.authorYi, Jin Kyu-
dc.contributor.authorIm, Sung Gap-
dc.contributor.authorKwon, Il Keun-
dc.date.accessioned2023-01-13T03:00:16Z-
dc.date.available2023-01-13T03:00:16Z-
dc.date.issued2015-
dc.identifier.citationJournal of Colloid and Interface Science, 2015, v. 439, p. 34-41-
dc.identifier.issn0021-9797-
dc.identifier.urihttp://hdl.handle.net/10722/323923-
dc.description.abstractInitiated chemical vapor deposition (iCVD) was utilized to generate a 200. nm thick, uniform, functionalized polymer nanolayer comprised of glycidyl methacrylate (GMA) on the surface of titanium implants as a means to improve cellular attachment. Dot-patterned GMA-coated specimens were prepared as well as fully coated specimens. In vitro cellular responses, including cell morphology, protein adsorption, cell proliferation assays, alkaline phosphate activity (ALP) assays, and calcium deposition assays were studied using adipose derived stem cells. The mechanical stability of the thin film was investigated by XPS and FE-SEM analysis of the GMA-coated implant after implantation to an extracted bone from a pig. The GMA-coated specimens displayed increased protein adsorption, higher alkaline phosphatase activities, and higher calcium deposition as compared to control sample with no cytotoxicity. Additionally, no defect was observed in the test of mechanical stability. Notably, dot-patterned GMA-coated samples displayed higher alkaline phosphatase activities than others. Functionalized polymer nanolayer deposition via iCVD is a flexible and robust technique capable of mass production of biocompatible layers. These properties make this technique very suitable for implant applications in a variety of ways.-
dc.languageeng-
dc.relation.ispartofJournal of Colloid and Interface Science-
dc.subjectFunctional polymer-
dc.subjectImplant-
dc.subjectInitiated chemical vapor deposition-
dc.subjectSurface treatment-
dc.titleGeneration of functionalized polymer nanolayer on implant surface via initiated chemical vapor deposition (iCVD)-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcis.2014.10.018-
dc.identifier.pmid25463173-
dc.identifier.scopuseid_2-s2.0-84909594679-
dc.identifier.volume439-
dc.identifier.spage34-
dc.identifier.epage41-
dc.identifier.eissn1095-7103-
dc.identifier.isiWOS:000346692500006-

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