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Article: The control of HIV transcription: Keeping RNA polymerase II on track

TitleThe control of HIV transcription: Keeping RNA polymerase II on track
Authors
Issue Date2011
Citation
Cell Host and Microbe, 2011, v. 10, n. 5, p. 426-435 How to Cite?
AbstractThirteen years ago, human cyclin T1 was identified as part of the positive transcription elongation factor b (P-TEFb) and the long-sought host cofactor for the HIV-1 transactivator Tat. Recent years have brought new insights into the intricate regulation of P-TEFb function and its relationship with Tat, revealing novel mechanisms for controlling HIV transcription and fueling new efforts to overcome the barrier of transcriptional latency in eradicating HIV. Moreover, the improved understanding of HIV and Tat forms a basis for studying transcription elongation control in general. Here, we review advances in HIV transcription research with a focus on the growing family of cellular P-TEFb complexes, structural insights into the interactions between Tat, P-TEFb, and TAR RNA, and the multifaceted regulation of these interactions by posttranscriptional modifications of Tat. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/323867
ISSN
2023 Impact Factor: 20.6
2023 SCImago Journal Rankings: 7.760
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOtt, Melanie-
dc.contributor.authorGeyer, Matthias-
dc.contributor.authorZhou, Qiang-
dc.date.accessioned2023-01-13T02:59:53Z-
dc.date.available2023-01-13T02:59:53Z-
dc.date.issued2011-
dc.identifier.citationCell Host and Microbe, 2011, v. 10, n. 5, p. 426-435-
dc.identifier.issn1931-3128-
dc.identifier.urihttp://hdl.handle.net/10722/323867-
dc.description.abstractThirteen years ago, human cyclin T1 was identified as part of the positive transcription elongation factor b (P-TEFb) and the long-sought host cofactor for the HIV-1 transactivator Tat. Recent years have brought new insights into the intricate regulation of P-TEFb function and its relationship with Tat, revealing novel mechanisms for controlling HIV transcription and fueling new efforts to overcome the barrier of transcriptional latency in eradicating HIV. Moreover, the improved understanding of HIV and Tat forms a basis for studying transcription elongation control in general. Here, we review advances in HIV transcription research with a focus on the growing family of cellular P-TEFb complexes, structural insights into the interactions between Tat, P-TEFb, and TAR RNA, and the multifaceted regulation of these interactions by posttranscriptional modifications of Tat. © 2011 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofCell Host and Microbe-
dc.titleThe control of HIV transcription: Keeping RNA polymerase II on track-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chom.2011.11.002-
dc.identifier.pmid22100159-
dc.identifier.scopuseid_2-s2.0-81755180766-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.spage426-
dc.identifier.epage435-
dc.identifier.eissn1934-6069-
dc.identifier.isiWOS:000297495100003-

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