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- Publisher Website: 10.5301/jabfm.5000389
- Scopus: eid_2-s2.0-85034422413
- PMID: 29131300
- WOS: WOS:000415072200002
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Article: Engineered scaffolds and cell-based therapy for periodontal regeneration
Title | Engineered scaffolds and cell-based therapy for periodontal regeneration |
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Authors | |
Keywords | Calcium phosphates Cell encapsulation Cell sheet technology Chitosan Multilayered scaffolds Regenerative periodontal therapy |
Issue Date | 2017 |
Citation | Journal of Applied Biomaterials and Functional Materials, 2017, v. 15, n. 4, p. e303-e312 How to Cite? |
Abstract | Background The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. Methods A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies. Results Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy. Conclusions Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved. |
Persistent Identifier | http://hdl.handle.net/10722/323498 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Carmagnola, Daniela | - |
dc.contributor.author | Tarce, Mihai | - |
dc.contributor.author | Dellavia, Claudia | - |
dc.contributor.author | Rimondini, Lia | - |
dc.contributor.author | Varoni, Elena M. | - |
dc.date.accessioned | 2023-01-06T14:10:12Z | - |
dc.date.available | 2023-01-06T14:10:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Applied Biomaterials and Functional Materials, 2017, v. 15, n. 4, p. e303-e312 | - |
dc.identifier.uri | http://hdl.handle.net/10722/323498 | - |
dc.description.abstract | Background The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. Methods A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies. Results Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy. Conclusions Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Applied Biomaterials and Functional Materials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Calcium phosphates | - |
dc.subject | Cell encapsulation | - |
dc.subject | Cell sheet technology | - |
dc.subject | Chitosan | - |
dc.subject | Multilayered scaffolds | - |
dc.subject | Regenerative periodontal therapy | - |
dc.title | Engineered scaffolds and cell-based therapy for periodontal regeneration | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.5301/jabfm.5000389 | - |
dc.identifier.pmid | 29131300 | - |
dc.identifier.scopus | eid_2-s2.0-85034422413 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | e303 | - |
dc.identifier.epage | e312 | - |
dc.identifier.eissn | 2280-8000 | - |
dc.identifier.isi | WOS:000415072200002 | - |