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- Publisher Website: 10.1038/srep34547
- Scopus: eid_2-s2.0-84989846593
- PMID: 27683067
- WOS: WOS:000384192800001
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Article: Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model
Title | Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model |
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Authors | |
Issue Date | 2016 |
Citation | Scientific Reports, 2016, v. 6, article no. 34547 How to Cite? |
Abstract | Portland cement used in the construction industry improves its properties when wet. Since most dental materials are used in a moist environment, Portland cement has been developed for use in dentistry. The first generation material is mineral trioxide aggregate (MTA), used in surgical procedures, thus in contact with blood. The aim of this study was to compare the setting of MTA in vitro and in vivo in contact with blood by subcutaneous implantation in rats. The tissue reaction to the material was also investigated. ProRoot MTA (Dentsply) was implanted in the subcutaneous tissues of Sprague-Dawley rats in opposite flanks and left in situ for 3 months. Furthermore the material was also stored in physiological solution in vitro. At the end of the incubation time, tissue histology and material characterization were performed. Surface assessment showed the formation of calcium carbonate for both environments. The bismuth was evident in the tissues thus showing heavy element contamination of the animal specimen. The tissue histology showed a chronic inflammatory cell infiltrate associated with the MTA. MTA interacts with the host tissues and causes a chronic inflammatory reaction when implanted subcutaneously. Hydration in vivo proceeds similarly to the in vitro model with some differences particularly in the bismuth oxide leaching patterns. |
Persistent Identifier | http://hdl.handle.net/10722/322066 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schembri Wismayer, P. | - |
dc.contributor.author | Lung, C. Y.K. | - |
dc.contributor.author | Rappa, F. | - |
dc.contributor.author | Cappello, F. | - |
dc.contributor.author | Camilleri, J. | - |
dc.date.accessioned | 2022-11-03T02:23:22Z | - |
dc.date.available | 2022-11-03T02:23:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Scientific Reports, 2016, v. 6, article no. 34547 | - |
dc.identifier.uri | http://hdl.handle.net/10722/322066 | - |
dc.description.abstract | Portland cement used in the construction industry improves its properties when wet. Since most dental materials are used in a moist environment, Portland cement has been developed for use in dentistry. The first generation material is mineral trioxide aggregate (MTA), used in surgical procedures, thus in contact with blood. The aim of this study was to compare the setting of MTA in vitro and in vivo in contact with blood by subcutaneous implantation in rats. The tissue reaction to the material was also investigated. ProRoot MTA (Dentsply) was implanted in the subcutaneous tissues of Sprague-Dawley rats in opposite flanks and left in situ for 3 months. Furthermore the material was also stored in physiological solution in vitro. At the end of the incubation time, tissue histology and material characterization were performed. Surface assessment showed the formation of calcium carbonate for both environments. The bismuth was evident in the tissues thus showing heavy element contamination of the animal specimen. The tissue histology showed a chronic inflammatory cell infiltrate associated with the MTA. MTA interacts with the host tissues and causes a chronic inflammatory reaction when implanted subcutaneously. Hydration in vivo proceeds similarly to the in vitro model with some differences particularly in the bismuth oxide leaching patterns. | - |
dc.language | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/srep34547 | - |
dc.identifier.pmid | 27683067 | - |
dc.identifier.pmcid | PMC5041115 | - |
dc.identifier.scopus | eid_2-s2.0-84989846593 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | article no. 34547 | - |
dc.identifier.epage | article no. 34547 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.isi | WOS:000384192800001 | - |