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Article: CD4+ T cell depletion does not affect the level of viremia in chronically SHIVSF162P3N-infected Chinese cynomolgus monkeys

TitleCD4<sup>+</sup> T cell depletion does not affect the level of viremia in chronically SHIV<inf>SF162P3N</inf>-infected Chinese cynomolgus monkeys
Authors
KeywordsCD4 T cell +
Cynomolgus
Depletion
SHIV
Viremia
Issue Date2021
Citation
Virology, 2021, v. 560, p. 76-85 How to Cite?
AbstractChronically SHIVSF162P3N-infected cynomolgus monkeys were used to determine the effects of the antibody-mediated acute CD4+ T cell depletion on viral load as well as on the immunological factors associated with disease progression. Compared with the control animals, CD4+ T cell-depleted animals with SHIV infection showed (i) little alteration in plasma viral load over the period of 22 weeks after the depletion; (ii) increased CD4+ T cell proliferation and turnover of macrophages at the early phase of the depletion, but subsequent decline to the basal levels; and (iii) little impact on the expression of the inflammatory cytokines and CC chemokines associated with disease progression. These findings indicate that the antibody-mediated acute CD4+ T cell depletion had minimal impact on plasma viral load and disease progression in chronically SHIVSF162P3N-infected cynomolgus monkeys. Future investigations are necessary to identify the key factor(s) related to the immune activation and macrophage infection during the CD4 deletion in chronic viral infection.
Persistent Identifierhttp://hdl.handle.net/10722/321937
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.838
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Hang-
dc.contributor.authorLiu, Jin Biao-
dc.contributor.authorMeng, Feng Zhen-
dc.contributor.authorXu, Xi Qiu-
dc.contributor.authorWang, Yong-
dc.contributor.authorXian, Qiao Yang-
dc.contributor.authorZhou, Run Hong-
dc.contributor.authorXiao, Qian Hao-
dc.contributor.authorHuang, Zhi Xiang-
dc.contributor.authorZhou, Li-
dc.contributor.authorLi, Jie Liang-
dc.contributor.authorLi, Xiang Dong-
dc.contributor.authorWang, Xu-
dc.contributor.authorHo, Wen Zhe-
dc.contributor.authorZhuang, Ke-
dc.date.accessioned2022-11-03T02:22:29Z-
dc.date.available2022-11-03T02:22:29Z-
dc.date.issued2021-
dc.identifier.citationVirology, 2021, v. 560, p. 76-85-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/321937-
dc.description.abstractChronically SHIVSF162P3N-infected cynomolgus monkeys were used to determine the effects of the antibody-mediated acute CD4+ T cell depletion on viral load as well as on the immunological factors associated with disease progression. Compared with the control animals, CD4+ T cell-depleted animals with SHIV infection showed (i) little alteration in plasma viral load over the period of 22 weeks after the depletion; (ii) increased CD4+ T cell proliferation and turnover of macrophages at the early phase of the depletion, but subsequent decline to the basal levels; and (iii) little impact on the expression of the inflammatory cytokines and CC chemokines associated with disease progression. These findings indicate that the antibody-mediated acute CD4+ T cell depletion had minimal impact on plasma viral load and disease progression in chronically SHIVSF162P3N-infected cynomolgus monkeys. Future investigations are necessary to identify the key factor(s) related to the immune activation and macrophage infection during the CD4 deletion in chronic viral infection.-
dc.languageeng-
dc.relation.ispartofVirology-
dc.subjectCD4 T cell +-
dc.subjectCynomolgus-
dc.subjectDepletion-
dc.subjectSHIV-
dc.subjectViremia-
dc.titleCD4<sup>+</sup> T cell depletion does not affect the level of viremia in chronically SHIV<inf>SF162P3N</inf>-infected Chinese cynomolgus monkeys-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2021.04.012-
dc.identifier.pmid34051477-
dc.identifier.scopuseid_2-s2.0-85106460539-
dc.identifier.volume560-
dc.identifier.spage76-
dc.identifier.epage85-
dc.identifier.eissn1096-0341-
dc.identifier.isiWOS:000659530700001-

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