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Article: IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex

TitleIFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex
Authors
Su, Qi JianWang, XuZhou, Run HongGuo, LeLiu, HangLi, Jie LiangHo, Wen Zhe
Issue Date2018
Citation
Scandinavian Journal of Immunology, 2018, v. 88, n. 5, article no. e12717 How to Cite?
DOI: http://dx.doi.org/10.1111/sji.12717
AbstractThe recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. This IFN-λ4-mediated HIV inhibition was compromised by the antibodies against IFN-λ receptor complex, IFN-λR1/IL-10R2. IFN-λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon-stimulated genes. These findings indicated that IFN-λ4 can inhibit HIV via JAK/STAT signalling pathway.
Persistent Identifierhttp://hdl.handle.net/10722/321808
ISSN
0300-9475
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 0.946
ISI Accession Number ID
WOS:000448086300004

 

DC FieldValueLanguage
dc.contributor.authorSu, Qi Jian-
dc.contributor.authorWang, Xu-
dc.contributor.authorZhou, Run Hong-
dc.contributor.authorGuo, Le-
dc.contributor.authorLiu, Hang-
dc.contributor.authorLi, Jie Liang-
dc.contributor.authorHo, Wen Zhe-
dc.date.accessioned2022-11-03T02:21:34Z-
dc.date.available2022-11-03T02:21:34Z-
dc.date.issued2018-
dc.identifier.citationScandinavian Journal of Immunology, 2018, v. 88, n. 5, article no. e12717-
dc.identifier.issn0300-9475-
dc.identifier.urihttp://hdl.handle.net/10722/321808-
dc.description.abstractThe recently discovered IFN-λ4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-λ4 can inhibit HIV infection. Here, we show that IFN-λ4 could suppress HIV infection of macrophages. This IFN-λ4-mediated HIV inhibition was compromised by the antibodies against IFN-λ receptor complex, IFN-λR1/IL-10R2. IFN-λ4 enhanced the phosphorylation of STAT1, and induced antiviral interferon-stimulated genes. These findings indicated that IFN-λ4 can inhibit HIV via JAK/STAT signalling pathway.-
dc.languageeng-
dc.relation.ispartofScandinavian Journal of Immunology-
dc.titleIFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/sji.12717-
dc.identifier.pmid30247785-
dc.identifier.scopuseid_2-s2.0-85054663889-
dc.identifier.volume88-
dc.identifier.issue5-
dc.identifier.spagearticle no. e12717-
dc.identifier.epagearticle no. e12717-
dc.identifier.eissn1365-3083-
dc.identifier.isiWOS:000448086300004-

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