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Article: Ongoing Spillover of Hantaan and Gou Hantaviruses from Rodents Is Associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in China

TitleOngoing Spillover of Hantaan and Gou Hantaviruses from Rodents Is Associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in China
Authors
Issue Date2013
Citation
PLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, article no. e2484 How to Cite?
AbstractBackground:Longquan City, Zhejiang province, China, has been seriously affected by hemorrhagic fever with renal syndrome (HFRS) since the first cases were registered in 1974. To understand the epidemiology and emergence of HFRS in Longquan, which may be indicative of large parts of rural China, we studied long-term incidence patterns and performed a molecular epidemiological investigation of the causative hantaviruses in human and rodent populations.Method/Principal Findings:During 1974-2011, 1866 cases of HFRS were recorded in Longquan, including 20 deaths. In 2011, the incidence of HFRS remained high, with 19.61 cases/100,000 population, despite the onset of vaccination in 1997. During 1974-1998, HFRS cases in Longquan occurred mainly in winter, while in the past decade the peak of HFRS has shifted to the spring. Notably, the concurrent prevalence of rodent-borne hantaviruses in the region was also high. Phylogenetic analyses of viral sequences recovered from rodents in Longquan revealed the presence of novel genetic variants of Gou virus (GOUV) in Rattus sp. rats and Hantaan virus (HTNV) in the stripe field mice, respectively. Strikingly, viral sequences sampled from infected humans were very closely related to those from rodents.Conclusions/Significance:HFRS represents an important public health problem in Longquan even after years of preventive measures. Our data suggest that continual spillover of the novel genetic variant of GOUV and the new genetic lineage of HTNV are responsible for the high prevalence of HFRS in humans. In addition, this is the first report of GOUV associated with human HFRS cases, and our data suggest that GOUV is now the major cause of HFRS in this region. © 2013 Wang et al.
Persistent Identifierhttp://hdl.handle.net/10722/321535
ISSN
2011 Impact Factor: 4.716
2023 SCImago Journal Rankings: 1.258
PubMed Central ID
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DC FieldValueLanguage
dc.contributor.authorWang, Wen-
dc.contributor.authorWang, Miao Ruo-
dc.contributor.authorLin, Xian Dan-
dc.contributor.authorGuo, Wen Ping-
dc.contributor.authorLi, Ming Hui-
dc.contributor.authorMei, Sheng Hua-
dc.contributor.authorLi, Zhao Mei-
dc.contributor.authorCong, Mei Li-
dc.contributor.authorJiang, Rui Lan-
dc.contributor.authorZhou, Run Hong-
dc.contributor.authorHolmes, Edward C.-
dc.contributor.authorPlyusnin, Alexander-
dc.contributor.authorZhang, Yong Zhen-
dc.date.accessioned2022-11-03T02:19:36Z-
dc.date.available2022-11-03T02:19:36Z-
dc.date.issued2013-
dc.identifier.citationPLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, article no. e2484-
dc.identifier.issn1935-2727-
dc.identifier.urihttp://hdl.handle.net/10722/321535-
dc.description.abstractBackground:Longquan City, Zhejiang province, China, has been seriously affected by hemorrhagic fever with renal syndrome (HFRS) since the first cases were registered in 1974. To understand the epidemiology and emergence of HFRS in Longquan, which may be indicative of large parts of rural China, we studied long-term incidence patterns and performed a molecular epidemiological investigation of the causative hantaviruses in human and rodent populations.Method/Principal Findings:During 1974-2011, 1866 cases of HFRS were recorded in Longquan, including 20 deaths. In 2011, the incidence of HFRS remained high, with 19.61 cases/100,000 population, despite the onset of vaccination in 1997. During 1974-1998, HFRS cases in Longquan occurred mainly in winter, while in the past decade the peak of HFRS has shifted to the spring. Notably, the concurrent prevalence of rodent-borne hantaviruses in the region was also high. Phylogenetic analyses of viral sequences recovered from rodents in Longquan revealed the presence of novel genetic variants of Gou virus (GOUV) in Rattus sp. rats and Hantaan virus (HTNV) in the stripe field mice, respectively. Strikingly, viral sequences sampled from infected humans were very closely related to those from rodents.Conclusions/Significance:HFRS represents an important public health problem in Longquan even after years of preventive measures. Our data suggest that continual spillover of the novel genetic variant of GOUV and the new genetic lineage of HTNV are responsible for the high prevalence of HFRS in humans. In addition, this is the first report of GOUV associated with human HFRS cases, and our data suggest that GOUV is now the major cause of HFRS in this region. © 2013 Wang et al.-
dc.languageeng-
dc.relation.ispartofPLoS Neglected Tropical Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleOngoing Spillover of Hantaan and Gou Hantaviruses from Rodents Is Associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in China-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pntd.0002484-
dc.identifier.pmid24147168-
dc.identifier.pmcidPMC3798614-
dc.identifier.scopuseid_2-s2.0-84887313774-
dc.identifier.volume7-
dc.identifier.issue10-
dc.identifier.spagearticle no. e2484-
dc.identifier.epagearticle no. e2484-
dc.identifier.eissn1935-2735-
dc.identifier.isiWOS:000330376500024-

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