File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1080/22221751.2022.2093135
- WOS: WOS:000820576600001
Supplementary
-
Citations:
- Web of Science: 0
- Appears in Collections:
Article: Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections
Title | Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections |
---|---|
Authors | |
Issue Date | 2022 |
Citation | Emerging Microbes & Infections, 2022, v. 11, p. 1742-1750 How to Cite? |
Abstract | There has been a rapid surge of hospitalization due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants globally. The severity of Omicron BA.2 in unexposed, unvaccinated, hospitalized children is unknown. We investigated the severity and clinical outcomes of COVID-19 infection during the Omicron wave in uninfected, unvaccinated hospitalized children and in comparison with influenza and parainfluenza viral infections. This population-based study retrieved data from the HK territory-wide CDARS database of hospitalisations in all public hospitals and compared severe outcomes for the Omicron BA.2-dominant fifth wave (5-28 February 2022, n = 1144), and influenza and parainfluenza viruses (1 January 2015-31 December 2019, n = 32212 and n = 16423, respectively) in children 0-11 years old. Two deaths (0.2%) out of 1144 cases during the initial Omicron wave were recorded. Twenty-one (1.8%) required PICU admission, and the relative risk was higher for Omicron than influenza virus (n = 254, 0.8%, adjusted RR = 2.1, 95%CI 1.3-3.3, p = 0.001). The proportion with neurological complications was 15.0% (n = 171) for Omicron, which was higher than influenza and parainfluenza viruses (n = 2707, 8.4%, adjusted RR = 1.6, 95%CI 1.4-1.9 and n = 1258, 7.7%, adjusted RR = 1.9, 95%CI 1.6-2.2, p < 0.001 for both, respectively). Croup occurred for Omicron (n = 61, 5.3%) more than influenza virus (n = 601, 1.9%, adjusted RR = 2.0, 95%CI 1.5-2.6, p < 0.001) but not parainfluenza virus (n = 889, 5.4%). Our findings showed that for hospitalized children who had no past COVID-19 or vaccination, Omicron BA.2 was not mild. Omicron BA.2 appeared to be more neuropathogenic than influenza and parainfluenza viruses. It targeted the upper airways more than influenza virus. |
Persistent Identifier | http://hdl.handle.net/10722/320116 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tso, WYW | - |
dc.contributor.author | Kwan, MYW | - |
dc.contributor.author | Wang, YL | - |
dc.contributor.author | Leung, LK | - |
dc.contributor.author | LEUNG, D | - |
dc.contributor.author | Chua, GT | - |
dc.contributor.author | Ip, P | - |
dc.contributor.author | Fong, DYT | - |
dc.contributor.author | Wong, WHS | - |
dc.contributor.author | Chan, HSS | - |
dc.contributor.author | Chan, JFW | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Lau, YL | - |
dc.contributor.author | Sou Da Rosa Duque, J | - |
dc.date.accessioned | 2022-10-21T07:47:15Z | - |
dc.date.available | 2022-10-21T07:47:15Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Emerging Microbes & Infections, 2022, v. 11, p. 1742-1750 | - |
dc.identifier.uri | http://hdl.handle.net/10722/320116 | - |
dc.description.abstract | There has been a rapid surge of hospitalization due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants globally. The severity of Omicron BA.2 in unexposed, unvaccinated, hospitalized children is unknown. We investigated the severity and clinical outcomes of COVID-19 infection during the Omicron wave in uninfected, unvaccinated hospitalized children and in comparison with influenza and parainfluenza viral infections. This population-based study retrieved data from the HK territory-wide CDARS database of hospitalisations in all public hospitals and compared severe outcomes for the Omicron BA.2-dominant fifth wave (5-28 February 2022, n = 1144), and influenza and parainfluenza viruses (1 January 2015-31 December 2019, n = 32212 and n = 16423, respectively) in children 0-11 years old. Two deaths (0.2%) out of 1144 cases during the initial Omicron wave were recorded. Twenty-one (1.8%) required PICU admission, and the relative risk was higher for Omicron than influenza virus (n = 254, 0.8%, adjusted RR = 2.1, 95%CI 1.3-3.3, p = 0.001). The proportion with neurological complications was 15.0% (n = 171) for Omicron, which was higher than influenza and parainfluenza viruses (n = 2707, 8.4%, adjusted RR = 1.6, 95%CI 1.4-1.9 and n = 1258, 7.7%, adjusted RR = 1.9, 95%CI 1.6-2.2, p < 0.001 for both, respectively). Croup occurred for Omicron (n = 61, 5.3%) more than influenza virus (n = 601, 1.9%, adjusted RR = 2.0, 95%CI 1.5-2.6, p < 0.001) but not parainfluenza virus (n = 889, 5.4%). Our findings showed that for hospitalized children who had no past COVID-19 or vaccination, Omicron BA.2 was not mild. Omicron BA.2 appeared to be more neuropathogenic than influenza and parainfluenza viruses. It targeted the upper airways more than influenza virus. | - |
dc.language | eng | - |
dc.relation.ispartof | Emerging Microbes & Infections | - |
dc.title | Severity of SARS-CoV-2 Omicron BA.2 infection in unvaccinated hospitalized children: comparison to influenza and parainfluenza infections | - |
dc.type | Article | - |
dc.identifier.email | Tso, WYW: wytso@hku.hk | - |
dc.identifier.email | Leung, LK: oscarlk@hku.hk | - |
dc.identifier.email | Ip, P: patricip@hku.hk | - |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | - |
dc.identifier.email | Wong, WHS: whswong@hku.hk | - |
dc.identifier.email | Chan, HSS: sophehs@hku.hk | - |
dc.identifier.email | Chan, JFW: jfwchan@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Lau, YL: lauylung@hku.hk | - |
dc.identifier.email | Sou Da Rosa Duque, J: jsrduque@hku.hk | - |
dc.identifier.authority | Tso, WYW=rp01517 | - |
dc.identifier.authority | Chua, GT=rp02684 | - |
dc.identifier.authority | Ip, P=rp01337 | - |
dc.identifier.authority | Fong, DYT=rp00253 | - |
dc.identifier.authority | Chan, HSS=rp02210 | - |
dc.identifier.authority | Chan, JFW=rp01736 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Lau, YL=rp00361 | - |
dc.identifier.authority | Sou Da Rosa Duque, J=rp02340 | - |
dc.identifier.doi | 10.1080/22221751.2022.2093135 | - |
dc.identifier.hkuros | 339734 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | 1742 | - |
dc.identifier.epage | 1750 | - |
dc.identifier.isi | WOS:000820576600001 | - |