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Article: Biomimetic mineralized hybrid scaffolds with antimicrobial peptides

TitleBiomimetic mineralized hybrid scaffolds with antimicrobial peptides
Authors
KeywordsAntimicrobial
Biomimetic mineralization
Cationic and amphipathic peptides
cytocompatibility
Hard tissue
Issue Date2021
Citation
Bioactive Materials, 2021, v. 6, n. 8, p. 2250-2260 How to Cite?
AbstractInfection in hard tissue regeneration is a clinically-relevant challenge. Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field. Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties. The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides. The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity. The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells. The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.
Persistent Identifierhttp://hdl.handle.net/10722/318903
ISSN
2023 Impact Factor: 18.0
2023 SCImago Journal Rankings: 3.466
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYe, Zhou-
dc.contributor.authorZhu, Xiao-
dc.contributor.authorMutreja, Isha-
dc.contributor.authorBoda, Sunil Kumar-
dc.contributor.authorFischer, Nicholas G.-
dc.contributor.authorZhang, Anqi-
dc.contributor.authorLui, Christine-
dc.contributor.authorQi, Yipin-
dc.contributor.authorAparicio, Conrado-
dc.date.accessioned2022-10-11T12:24:49Z-
dc.date.available2022-10-11T12:24:49Z-
dc.date.issued2021-
dc.identifier.citationBioactive Materials, 2021, v. 6, n. 8, p. 2250-2260-
dc.identifier.issn2452-199X-
dc.identifier.urihttp://hdl.handle.net/10722/318903-
dc.description.abstractInfection in hard tissue regeneration is a clinically-relevant challenge. Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field. Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties. The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides. The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity. The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells. The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.-
dc.languageeng-
dc.relation.ispartofBioactive Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntimicrobial-
dc.subjectBiomimetic mineralization-
dc.subjectCationic and amphipathic peptides-
dc.subjectcytocompatibility-
dc.subjectHard tissue-
dc.titleBiomimetic mineralized hybrid scaffolds with antimicrobial peptides-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.bioactmat.2020.12.029-
dc.identifier.pmid33553813-
dc.identifier.pmcidPMC7829078-
dc.identifier.scopuseid_2-s2.0-85099815121-
dc.identifier.volume6-
dc.identifier.issue8-
dc.identifier.spage2250-
dc.identifier.epage2260-
dc.identifier.isiWOS:000648343800003-

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