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- Publisher Website: 10.1080/23723556.2016.1179381
- Scopus: eid_2-s2.0-85050720161
- WOS: WOS:000389179300016
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Article: Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma
| Title | Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma |
|---|---|
| Authors | |
| Keywords | BRAF-mutant melanoma mitochondrial biogenesis targeted therapies |
| Issue Date | 2016 |
| Citation | Molecular and Cellular Oncology, 2016, v. 3, n. 4, article no. e1179381 How to Cite? |
| Abstract | The acquisition of resistance to current mitogen activated protein kinase (MAPK) inhibitors in B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutant melanoma is almost inevitable. Our recent findings identify therapy-induced mitochondrial biogenesis (MitoBiogenesis) and aberrant tumor bioenergetics as therapeutic escape mechanisms and offer a rational combinatorial strategy to further improve the efficacy of MAPK inhibitors. |
| Persistent Identifier | http://hdl.handle.net/10722/318723 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wu, Lawrence W. | - |
| dc.contributor.author | Zhang, Gao | - |
| dc.contributor.author | Herlyn, Meenhard | - |
| dc.date.accessioned | 2022-10-11T12:24:24Z | - |
| dc.date.available | 2022-10-11T12:24:24Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | Molecular and Cellular Oncology, 2016, v. 3, n. 4, article no. e1179381 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/318723 | - |
| dc.description.abstract | The acquisition of resistance to current mitogen activated protein kinase (MAPK) inhibitors in B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutant melanoma is almost inevitable. Our recent findings identify therapy-induced mitochondrial biogenesis (MitoBiogenesis) and aberrant tumor bioenergetics as therapeutic escape mechanisms and offer a rational combinatorial strategy to further improve the efficacy of MAPK inhibitors. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Molecular and Cellular Oncology | - |
| dc.subject | BRAF-mutant melanoma | - |
| dc.subject | mitochondrial biogenesis | - |
| dc.subject | targeted therapies | - |
| dc.title | Mitochondrial biogenesis meets chemoresistance in BRAF-mutant melanoma | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1080/23723556.2016.1179381 | - |
| dc.identifier.scopus | eid_2-s2.0-85050720161 | - |
| dc.identifier.volume | 3 | - |
| dc.identifier.issue | 4 | - |
| dc.identifier.spage | article no. e1179381 | - |
| dc.identifier.epage | article no. e1179381 | - |
| dc.identifier.eissn | 2372-3556 | - |
| dc.identifier.isi | WOS:000389179300016 | - |