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- Publisher Website: 10.1007/s10544-009-9350-4
- Scopus: eid_2-s2.0-70549091184
- PMID: 19806459
- WOS: WOS:000271721000018
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Article: 3D microfabricated bioreactor with capillaries
| Title | 3D microfabricated bioreactor with capillaries |
|---|---|
| Authors | |
| Keywords | 3D microfabrication Bioreactor Modeling Transport Vascular |
| Issue Date | 2009 |
| Citation | Biomedical Microdevices, 2009, v. 11, n. 6, p. 1309-1315 How to Cite? |
| Abstract | We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PμSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PμSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications. © 2009 Springer Science+Business Media, LLC. |
| Persistent Identifier | http://hdl.handle.net/10722/318469 |
| ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.578 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Xia, Chunguang | - |
| dc.contributor.author | Fang, Nicholas X. | - |
| dc.date.accessioned | 2022-10-11T12:23:50Z | - |
| dc.date.available | 2022-10-11T12:23:50Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.citation | Biomedical Microdevices, 2009, v. 11, n. 6, p. 1309-1315 | - |
| dc.identifier.issn | 1387-2176 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/318469 | - |
| dc.description.abstract | We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PμSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PμSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications. © 2009 Springer Science+Business Media, LLC. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Biomedical Microdevices | - |
| dc.subject | 3D microfabrication | - |
| dc.subject | Bioreactor | - |
| dc.subject | Modeling | - |
| dc.subject | Transport | - |
| dc.subject | Vascular | - |
| dc.title | 3D microfabricated bioreactor with capillaries | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1007/s10544-009-9350-4 | - |
| dc.identifier.pmid | 19806459 | - |
| dc.identifier.scopus | eid_2-s2.0-70549091184 | - |
| dc.identifier.volume | 11 | - |
| dc.identifier.issue | 6 | - |
| dc.identifier.spage | 1309 | - |
| dc.identifier.epage | 1315 | - |
| dc.identifier.isi | WOS:000271721000018 | - |