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- Publisher Website: 10.1016/j.jad.2022.07.026
- WOS: WOS:000848145600018
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Article: Meta-analysis of diagnostic properties of the Whooley questions to identify depression in perinatal women
Title | Meta-analysis of diagnostic properties of the Whooley questions to identify depression in perinatal women |
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Authors | |
Issue Date | 2022 |
Citation | Journal of Affective Disorders, 2022, v. 315, p. 148-155 How to Cite? |
Abstract | Background: This study's objective was to assess the diagnostic properties of the Whooley questions in identifying depression among perinatal women according to previously published studies. We conducted a systematic review and meta-analysis of studies investigating the diagnostic accuracy of the Whooley questions in perinatal women. Methods: Nine databases were searched in October 2021. All primary studies evaluated the diagnostic properties of the Whooley questions compared with a diagnostic gold standard in women during the perinatal period or, if not identified as being in the perinatal stage within the study, women between 20 weeks' gestation to 4 weeks post-delivery. A bivariate mixed-effects meta-analysis was performed to estimate pooled diagnostic properties and measure heterogeneity. Meta-regression was conducted to evaluate factors contributing to heterogeneity. Results: Six studies were included in the review; five were used in the meta-analysis. The pooled sensitivity (95 % confidence interval) was 0.95 (0.81-0.99), pooled specificity was 0.60 (0.44-0.74), pooled positive likelihood ratio was 2.4 (1.6-3.4), pooled negative likelihood ratio was 0.09 (0.02-0.32), and pooled diagnostic odds ratio was 27 (7-106); heterogeneity was substantial (I2 = 0.90, 0.81-1.00). Participant age and setting (community vs. hospital) significantly contributed to heterogeneity. Conclusions: The Whooley questions have high sensitivity but moderate specificity for perinatal women. The Whooley questions are a short and acceptable tool for identifying depression in perinatal women. However, a potential risk exists of incorrectly identifying a high proportion of women as positive. Using the Whooley questions followed by a secondary case-finding tool could reduce the misdiagnosis risk. |
Persistent Identifier | http://hdl.handle.net/10722/317589 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Smith, RD | - |
dc.contributor.author | SHING, SY | - |
dc.contributor.author | Lin, JJ | - |
dc.contributor.author | Bosanquet, K | - |
dc.contributor.author | Fong, DYT | - |
dc.contributor.author | Lok, YWK | - |
dc.date.accessioned | 2022-10-07T10:23:18Z | - |
dc.date.available | 2022-10-07T10:23:18Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Journal of Affective Disorders, 2022, v. 315, p. 148-155 | - |
dc.identifier.uri | http://hdl.handle.net/10722/317589 | - |
dc.description.abstract | Background: This study's objective was to assess the diagnostic properties of the Whooley questions in identifying depression among perinatal women according to previously published studies. We conducted a systematic review and meta-analysis of studies investigating the diagnostic accuracy of the Whooley questions in perinatal women. Methods: Nine databases were searched in October 2021. All primary studies evaluated the diagnostic properties of the Whooley questions compared with a diagnostic gold standard in women during the perinatal period or, if not identified as being in the perinatal stage within the study, women between 20 weeks' gestation to 4 weeks post-delivery. A bivariate mixed-effects meta-analysis was performed to estimate pooled diagnostic properties and measure heterogeneity. Meta-regression was conducted to evaluate factors contributing to heterogeneity. Results: Six studies were included in the review; five were used in the meta-analysis. The pooled sensitivity (95 % confidence interval) was 0.95 (0.81-0.99), pooled specificity was 0.60 (0.44-0.74), pooled positive likelihood ratio was 2.4 (1.6-3.4), pooled negative likelihood ratio was 0.09 (0.02-0.32), and pooled diagnostic odds ratio was 27 (7-106); heterogeneity was substantial (I2 = 0.90, 0.81-1.00). Participant age and setting (community vs. hospital) significantly contributed to heterogeneity. Conclusions: The Whooley questions have high sensitivity but moderate specificity for perinatal women. The Whooley questions are a short and acceptable tool for identifying depression in perinatal women. However, a potential risk exists of incorrectly identifying a high proportion of women as positive. Using the Whooley questions followed by a secondary case-finding tool could reduce the misdiagnosis risk. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Affective Disorders | - |
dc.title | Meta-analysis of diagnostic properties of the Whooley questions to identify depression in perinatal women | - |
dc.type | Article | - |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | - |
dc.identifier.email | Lok, YWK: krislok@hku.hk | - |
dc.identifier.authority | Lin, JJ=rp02218 | - |
dc.identifier.authority | Fong, DYT=rp00253 | - |
dc.identifier.authority | Lok, YWK=rp02172 | - |
dc.identifier.doi | 10.1016/j.jad.2022.07.026 | - |
dc.identifier.hkuros | 337034 | - |
dc.identifier.volume | 315 | - |
dc.identifier.spage | 148 | - |
dc.identifier.epage | 155 | - |
dc.identifier.isi | WOS:000848145600018 | - |