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Article: Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging

TitleAptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
Authors
Issue Date2022
Citation
Cells, 2022, v. 11, p. 159 How to Cite?
AbstractA wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application.
Persistent Identifierhttp://hdl.handle.net/10722/317278

 

DC FieldValueLanguage
dc.contributor.authorLIU, M-
dc.contributor.authorWANG, L-
dc.contributor.authorLo, Y-
dc.contributor.authorShiu, SCC-
dc.contributor.authorKinghorn, AB-
dc.contributor.authorTanner, JA-
dc.date.accessioned2022-10-07T10:17:37Z-
dc.date.available2022-10-07T10:17:37Z-
dc.date.issued2022-
dc.identifier.citationCells, 2022, v. 11, p. 159-
dc.identifier.urihttp://hdl.handle.net/10722/317278-
dc.description.abstractA wide variety of nanomaterials have emerged in recent years with advantageous properties for a plethora of therapeutic and diagnostic applications. Such applications include drug delivery, imaging, anti-cancer therapy and radiotherapy. There is a critical need for further components which can facilitate therapeutic targeting, augment their physicochemical properties, or broaden their theranostic applications. Aptamers are single-stranded nucleic acids which have been selected or evolved to bind specifically to molecules, surfaces, or cells. Aptamers can also act as direct biologic therapeutics, or in imaging and diagnostics. There is a rich field of discovery at the interdisciplinary interface between nanomaterials and aptamer science that has significant potential across biomedicine. Herein, we review recent progress in aptamer-enabled materials and discuss pending challenges for their future biomedical application.-
dc.languageeng-
dc.relation.ispartofCells-
dc.titleAptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging-
dc.typeArticle-
dc.identifier.emailTanner, JA: jatanner@hkucc.hku.hk-
dc.identifier.authorityTanner, JA=rp00495-
dc.identifier.doi10.3390/cells11010159-
dc.identifier.hkuros337232-
dc.identifier.volume11-
dc.identifier.spage159-
dc.identifier.epage159-

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