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- Publisher Website: 10.1093/infdis/jiw208
- Scopus: eid_2-s2.0-84988973643
- PMID: 27354370
- WOS: WOS:000384849600007
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Article: The evolution and transmission of epidemic gii.17 noroviruses
Title | The evolution and transmission of epidemic gii.17 noroviruses |
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Authors | |
Keywords | Epidemic Norovirus Phylogenetic Phylogeographic Virus transmission |
Issue Date | 2016 |
Citation | Journal of Infectious Diseases, 2016, v. 214, n. 4, p. 556-564 How to Cite? |
Abstract | Background. In recent decades, the GII.4 norovirus genotype has predominated in epidemics worldwide and been associated with an increased rate of evolutionary change. In 2014, a novel GII.17 variant emerged and persisted, causing large outbreaks of gastroenteritis in China and sporadic infections globally. The origin, evolution, and transmission history of this new variant are largely unknown. Methods. We generated 103 full capsid and 8 whole-genome sequences of GII.17 strains collected between August 2013 and November 2015 in Guangdong, China. Phylogenetic analyses were performed by integrating our data with those for all publically available GII.17 sequences. Results. The novel emergent lineage GII.17-Kawasaki-2014most likely originated from Africa around 2001 and evolved at a rate of 5.6 × 10?3 substitutions/site/year.Within this lineage, a new variant containing several important amino acid changes emerged around August 2013 and caused extensive epidemics in 2014-2015. The phylodynamic and epidemic history of the GII.17-Kawasaki lineage shows similarities with the pattern observed for GII.4 norovirus evolution. Virus movements from Hong Kong to neighboring coastal cities were frequently observed. Conclusions. Our results provide new insights into GII.17 norovirus evolution and transmission and highlight the potential for a rare norovirus genotype to rapidly replace existing strains and cause local epidemics. |
Persistent Identifier | http://hdl.handle.net/10722/316453 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 2.387 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lu, Jing | - |
dc.contributor.author | Fang, Lin | - |
dc.contributor.author | Zheng, Huanying | - |
dc.contributor.author | Lao, Jiaqian | - |
dc.contributor.author | Yang, Fen | - |
dc.contributor.author | Sun, Limei | - |
dc.contributor.author | Xiao, Jianpeng | - |
dc.contributor.author | Lin, Jinyan | - |
dc.contributor.author | Song, Tie | - |
dc.contributor.author | Ni, Tao | - |
dc.contributor.author | Raghwani, Jayna | - |
dc.contributor.author | Ke, Changwen | - |
dc.contributor.author | Faria, Nuno R. | - |
dc.contributor.author | Bowden, Thomas A. | - |
dc.contributor.author | Pybus, Oliver G. | - |
dc.contributor.author | Li, Hui | - |
dc.date.accessioned | 2022-09-14T11:40:29Z | - |
dc.date.available | 2022-09-14T11:40:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of Infectious Diseases, 2016, v. 214, n. 4, p. 556-564 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/10722/316453 | - |
dc.description.abstract | Background. In recent decades, the GII.4 norovirus genotype has predominated in epidemics worldwide and been associated with an increased rate of evolutionary change. In 2014, a novel GII.17 variant emerged and persisted, causing large outbreaks of gastroenteritis in China and sporadic infections globally. The origin, evolution, and transmission history of this new variant are largely unknown. Methods. We generated 103 full capsid and 8 whole-genome sequences of GII.17 strains collected between August 2013 and November 2015 in Guangdong, China. Phylogenetic analyses were performed by integrating our data with those for all publically available GII.17 sequences. Results. The novel emergent lineage GII.17-Kawasaki-2014most likely originated from Africa around 2001 and evolved at a rate of 5.6 × 10?3 substitutions/site/year.Within this lineage, a new variant containing several important amino acid changes emerged around August 2013 and caused extensive epidemics in 2014-2015. The phylodynamic and epidemic history of the GII.17-Kawasaki lineage shows similarities with the pattern observed for GII.4 norovirus evolution. Virus movements from Hong Kong to neighboring coastal cities were frequently observed. Conclusions. Our results provide new insights into GII.17 norovirus evolution and transmission and highlight the potential for a rare norovirus genotype to rapidly replace existing strains and cause local epidemics. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.subject | Epidemic | - |
dc.subject | Norovirus | - |
dc.subject | Phylogenetic | - |
dc.subject | Phylogeographic | - |
dc.subject | Virus transmission | - |
dc.title | The evolution and transmission of epidemic gii.17 noroviruses | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/infdis/jiw208 | - |
dc.identifier.pmid | 27354370 | - |
dc.identifier.scopus | eid_2-s2.0-84988973643 | - |
dc.identifier.volume | 214 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 556 | - |
dc.identifier.epage | 564 | - |
dc.identifier.eissn | 1537-6613 | - |
dc.identifier.isi | WOS:000384849600007 | - |