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Article: Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease

TitleImage texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease
Authors
Keywordsgray-level co-occurrence matrix
magnetic resonance imaging
multiple linear regression
polycystic kidney disease
total kidney volume
Issue Date2017
Citation
Kidney International, 2017, v. 92, n. 5, p. 1206-1216 How to Cite?
AbstractMagnetic resonance imaging (MRI) examinations provide high-resolution information about the anatomic structure of the kidneys and are used to measure total kidney volume (TKV) in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Height-adjusted TKV (HtTKV) has become the gold-standard imaging biomarker for ADPKD progression at early stages of the disease when estimated glomerular filtration rate (eGFR) is still normal. However, HtTKV does not take advantage of the wealth of information provided by MRI. Here we tested whether image texture features provide additional insights into the ADPKD kidney that may be used as complementary information to existing biomarkers. A retrospective cohort of 122 patients from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study was identified who had T2-weighted MRIs and eGFR values over 70 mL/min/1.73m2 at the time of their baseline scan. We computed nine distinct image texture features for each patient. The ability of each feature to predict subsequent progression to CKD stage 3A, 3B, and 30% reduction in eGFR at eight-year follow-up was assessed. A multiple linear regression model was developed incorporating age, baseline eGFR, HtTKV, and three image texture features identified by stability feature selection (Entropy, Correlation, and Energy). Including texture in a multiple linear regression model (predicting percent change in eGFR) improved Pearson correlation coefficient from -0.51 (using age, eGFR, and HtTKV) to -0.70 (adding texture). Thus, texture analysis offers an approach to refine ADPKD prognosis and should be further explored for its utility in individualized clinical decision making and outcome prediction.
Persistent Identifierhttp://hdl.handle.net/10722/316145
ISSN
2023 Impact Factor: 14.8
2023 SCImago Journal Rankings: 3.886
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKline, Timothy L.-
dc.contributor.authorKorfiatis, Panagiotis-
dc.contributor.authorEdwards, Marie E.-
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorYu, Alan-
dc.contributor.authorChapman, Arlene B.-
dc.contributor.authorMrug, Michal-
dc.contributor.authorGrantham, Jared J.-
dc.contributor.authorLandsittel, Douglas-
dc.contributor.authorBennett, William M.-
dc.contributor.authorKing, Bernard F.-
dc.contributor.authorHarris, Peter C.-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorErickson, Bradley J.-
dc.date.accessioned2022-08-24T15:49:24Z-
dc.date.available2022-08-24T15:49:24Z-
dc.date.issued2017-
dc.identifier.citationKidney International, 2017, v. 92, n. 5, p. 1206-1216-
dc.identifier.issn0085-2538-
dc.identifier.urihttp://hdl.handle.net/10722/316145-
dc.description.abstractMagnetic resonance imaging (MRI) examinations provide high-resolution information about the anatomic structure of the kidneys and are used to measure total kidney volume (TKV) in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Height-adjusted TKV (HtTKV) has become the gold-standard imaging biomarker for ADPKD progression at early stages of the disease when estimated glomerular filtration rate (eGFR) is still normal. However, HtTKV does not take advantage of the wealth of information provided by MRI. Here we tested whether image texture features provide additional insights into the ADPKD kidney that may be used as complementary information to existing biomarkers. A retrospective cohort of 122 patients from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) study was identified who had T2-weighted MRIs and eGFR values over 70 mL/min/1.73m2 at the time of their baseline scan. We computed nine distinct image texture features for each patient. The ability of each feature to predict subsequent progression to CKD stage 3A, 3B, and 30% reduction in eGFR at eight-year follow-up was assessed. A multiple linear regression model was developed incorporating age, baseline eGFR, HtTKV, and three image texture features identified by stability feature selection (Entropy, Correlation, and Energy). Including texture in a multiple linear regression model (predicting percent change in eGFR) improved Pearson correlation coefficient from -0.51 (using age, eGFR, and HtTKV) to -0.70 (adding texture). Thus, texture analysis offers an approach to refine ADPKD prognosis and should be further explored for its utility in individualized clinical decision making and outcome prediction.-
dc.languageeng-
dc.relation.ispartofKidney International-
dc.subjectgray-level co-occurrence matrix-
dc.subjectmagnetic resonance imaging-
dc.subjectmultiple linear regression-
dc.subjectpolycystic kidney disease-
dc.subjecttotal kidney volume-
dc.titleImage texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.kint.2017.03.026-
dc.identifier.pmid28532709-
dc.identifier.scopuseid_2-s2.0-85019847342-
dc.identifier.volume92-
dc.identifier.issue5-
dc.identifier.spage1206-
dc.identifier.epage1216-
dc.identifier.eissn1523-1755-
dc.identifier.isiWOS:000413267700021-

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