File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Automated segmentation of kidneys from mr images in patients with autosomal dominant polycystic kidney disease

TitleAutomated segmentation of kidneys from mr images in patients with autosomal dominant polycystic kidney disease
Authors
Issue Date2016
Citation
Clinical Journal of the American Society of Nephrology, 2016, v. 11, n. 4, p. 576-584 How to Cite?
AbstractBackground and objectives Our study developed a fully automated method for segmentation and volumetric measurements of kidneys from magnetic resonance images in patients with autosomal dominant polycystic kidney disease and assessed the performance of the automated method with the reference manual segmentation method. Design, setting, participants, & measurements Study patients were selected from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. At the enrollment of the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease Study in 2000, patients with autosomal dominant polycystic kidney disease were between 15 and 46 years of age with relatively preserved GFRs. Our fully automated segmentation method was on the basis of a spatial prior probability map of the location of kidneys in abdominal magnetic resonance images and regional mapping with total variation regularization and propagated shape constraints that were formulated into a level set framework. T2–weighted magnetic resonance image sets of 120 kidneys were selected from 60 patients with autosomal dominant polycystic kidney disease and divided into the training and test datasets. The performance of the automated method in reference to the manual method was assessed by means of two metrics: Dice similarity coefficient and intraclass correlation coefficient of segmented kidney volume. The training and test sets were swapped for crossvalidation and reanalyzed. Results Successful segmentation of kidneys was performed with the automated method in all test patients. The segmented kidney volumes ranged from 177.2 to 2634 ml (mean, 885.4±569.7 ml). The mean Dice similarity coefficient ±SD between the automated and manual methods was 0.88±0.08. The mean correlation coefficient between the two segmentation methods for the segmented volume measurements was 0.97 (P<0.001 for each crossvalidation set). The results from the crossvalidation sets were highly comparable. Conclusions We have developed a fully automated method for segmentation of kidneys from abdominal magnetic resonance images in patients with autosomal dominant polycystic kidney disease with varying kidney volumes. The performance of the automated method was in good agreement with that of manual method.
Persistent Identifierhttp://hdl.handle.net/10722/316142
ISSN
2023 Impact Factor: 8.5
2023 SCImago Journal Rankings: 2.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKim, Youngwoo-
dc.contributor.authorGe, Yinghui-
dc.contributor.authorTao, Cheng-
dc.contributor.authorZhu, Jianbing-
dc.contributor.authorChapman, Arlene B.-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorYu, Alan S.L.-
dc.contributor.authorMrug, Michal-
dc.contributor.authorBennett, William M.-
dc.contributor.authorFlessner, Michael F.-
dc.contributor.authorLandsittel, Doug P.-
dc.contributor.authorBae, Kyongtae T.-
dc.date.accessioned2022-08-24T15:49:23Z-
dc.date.available2022-08-24T15:49:23Z-
dc.date.issued2016-
dc.identifier.citationClinical Journal of the American Society of Nephrology, 2016, v. 11, n. 4, p. 576-584-
dc.identifier.issn1555-9041-
dc.identifier.urihttp://hdl.handle.net/10722/316142-
dc.description.abstractBackground and objectives Our study developed a fully automated method for segmentation and volumetric measurements of kidneys from magnetic resonance images in patients with autosomal dominant polycystic kidney disease and assessed the performance of the automated method with the reference manual segmentation method. Design, setting, participants, & measurements Study patients were selected from the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease. At the enrollment of the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease Study in 2000, patients with autosomal dominant polycystic kidney disease were between 15 and 46 years of age with relatively preserved GFRs. Our fully automated segmentation method was on the basis of a spatial prior probability map of the location of kidneys in abdominal magnetic resonance images and regional mapping with total variation regularization and propagated shape constraints that were formulated into a level set framework. T2–weighted magnetic resonance image sets of 120 kidneys were selected from 60 patients with autosomal dominant polycystic kidney disease and divided into the training and test datasets. The performance of the automated method in reference to the manual method was assessed by means of two metrics: Dice similarity coefficient and intraclass correlation coefficient of segmented kidney volume. The training and test sets were swapped for crossvalidation and reanalyzed. Results Successful segmentation of kidneys was performed with the automated method in all test patients. The segmented kidney volumes ranged from 177.2 to 2634 ml (mean, 885.4±569.7 ml). The mean Dice similarity coefficient ±SD between the automated and manual methods was 0.88±0.08. The mean correlation coefficient between the two segmentation methods for the segmented volume measurements was 0.97 (P<0.001 for each crossvalidation set). The results from the crossvalidation sets were highly comparable. Conclusions We have developed a fully automated method for segmentation of kidneys from abdominal magnetic resonance images in patients with autosomal dominant polycystic kidney disease with varying kidney volumes. The performance of the automated method was in good agreement with that of manual method.-
dc.languageeng-
dc.relation.ispartofClinical Journal of the American Society of Nephrology-
dc.titleAutomated segmentation of kidneys from mr images in patients with autosomal dominant polycystic kidney disease-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2215/CJN.08300815-
dc.identifier.pmid26797708-
dc.identifier.scopuseid_2-s2.0-85011593679-
dc.identifier.volume11-
dc.identifier.issue4-
dc.identifier.spage576-
dc.identifier.epage584-
dc.identifier.eissn1555-905X-
dc.identifier.isiWOS:000373522600007-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats