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Article: MRI-based kidney volume measurements in ADPKD: Reliability and effect of gadolinium enhancement

TitleMRI-based kidney volume measurements in ADPKD: Reliability and effect of gadolinium enhancement
Authors
Issue Date2009
Citation
Clinical Journal of the American Society of Nephrology, 2009, v. 4, n. 4, p. 719-725 How to Cite?
AbstractBackground and objectives: To evaluate the inter- and intrareader reliability and the effect of gadolinium enhancement on kidney volume measurements obtained from pre- and postgadolinium T1 MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). Design, setting, participants, & measurements: Twenty subjects were randomly selected with approximately equal frequency from three kidney-size groups. Pre- and postgadolinium 3D T1 (pre-T1, post-T1) MR images were obtained. The stereology method was applied to segment and measure kidney volumes. The measurement process was repeated at two-wk intervals by two radiologists. Reliability was assessed with correlation coefficients. Intra- and inter-reader bias and measure differences were assessed with paired T-tests. The size effect on the pre- and post-T1 measurements was evaluated with one-way ANOVA. Results: The intra- and inter-reader reliability was extremely high in all measurements. No systematic intrareader bias but a small inter-reader bias for the post-T1 measurements was observed. All kidney volumes measured on the pre- and post-T1 images were highly correlated with each other for both readers. The post-T1 volumes were significantly higher than pre-T1 volumes. While the post-pre volume differences were relatively constant across the three kidney-size groups, the post-pre percent volume differences were significantly smaller as the size of the kidney increased. Conclusions: Kidney volume measurements can be made with minimum intra- and inter-reader variability on both pre- and post-T1 MR images. Kidney volumes measured on the pre-T1 were smaller than those on post-T1, and percent differences between pre-T1 and post-T1 kidney volumes decreased with increasing kidney size. Copyright © 2009 by the American Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/316022
ISSN
2023 Impact Factor: 8.5
2023 SCImago Journal Rankings: 2.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBae, Kyongtae T.-
dc.contributor.authorTao, Cheng-
dc.contributor.authorZhu, Fang-
dc.contributor.authorBost, James E.-
dc.contributor.authorChapman, Arlene B.-
dc.contributor.authorGrantham, Jared J.-
dc.contributor.authorTorres, Vicente E.-
dc.contributor.authorGuay-Woodford, Lisa M.-
dc.contributor.authorMeyers, Catherine M.-
dc.contributor.authorBennett, William M.-
dc.date.accessioned2022-08-24T15:48:58Z-
dc.date.available2022-08-24T15:48:58Z-
dc.date.issued2009-
dc.identifier.citationClinical Journal of the American Society of Nephrology, 2009, v. 4, n. 4, p. 719-725-
dc.identifier.issn1555-9041-
dc.identifier.urihttp://hdl.handle.net/10722/316022-
dc.description.abstractBackground and objectives: To evaluate the inter- and intrareader reliability and the effect of gadolinium enhancement on kidney volume measurements obtained from pre- and postgadolinium T1 MR images in patients with autosomal dominant polycystic kidney disease (ADPKD). Design, setting, participants, & measurements: Twenty subjects were randomly selected with approximately equal frequency from three kidney-size groups. Pre- and postgadolinium 3D T1 (pre-T1, post-T1) MR images were obtained. The stereology method was applied to segment and measure kidney volumes. The measurement process was repeated at two-wk intervals by two radiologists. Reliability was assessed with correlation coefficients. Intra- and inter-reader bias and measure differences were assessed with paired T-tests. The size effect on the pre- and post-T1 measurements was evaluated with one-way ANOVA. Results: The intra- and inter-reader reliability was extremely high in all measurements. No systematic intrareader bias but a small inter-reader bias for the post-T1 measurements was observed. All kidney volumes measured on the pre- and post-T1 images were highly correlated with each other for both readers. The post-T1 volumes were significantly higher than pre-T1 volumes. While the post-pre volume differences were relatively constant across the three kidney-size groups, the post-pre percent volume differences were significantly smaller as the size of the kidney increased. Conclusions: Kidney volume measurements can be made with minimum intra- and inter-reader variability on both pre- and post-T1 MR images. Kidney volumes measured on the pre-T1 were smaller than those on post-T1, and percent differences between pre-T1 and post-T1 kidney volumes decreased with increasing kidney size. Copyright © 2009 by the American Society of Nephrology.-
dc.languageeng-
dc.relation.ispartofClinical Journal of the American Society of Nephrology-
dc.titleMRI-based kidney volume measurements in ADPKD: Reliability and effect of gadolinium enhancement-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2215/CJN.03750708-
dc.identifier.pmid19339416-
dc.identifier.scopuseid_2-s2.0-66449117932-
dc.identifier.volume4-
dc.identifier.issue4-
dc.identifier.spage719-
dc.identifier.epage725-
dc.identifier.eissn1555-905X-
dc.identifier.isiWOS:000264937900010-

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