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postgraduate thesis: Investigating the effects of systemic immune responses on the infiltration of peripheral macrophages into the brain
Title | Investigating the effects of systemic immune responses on the infiltration of peripheral macrophages into the brain |
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Authors | |
Issue Date | 2022 |
Publisher | The University of Hong Kong (Pokfulam, Hong Kong) |
Citation | Yan, T. [殷浩翔]. (2022). Investigating the effects of systemic immune responses on the infiltration of peripheral macrophages into the brain. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. |
Abstract | Postoperative cognitive dysfunction (POCD) is a complication occurring days to
months after surgery causing deficits in memory, executive functions and other cognitive
abilities. It is especially prevalent among the elderly, which makes it an increasingly important
healthcare problem as population aging becomes progressively severe in Hong Kong.
A lot of research has been conducted in hopes of uncovering the mechanisms behind
POCD, with limited success. Anaesthesia used during surgery was first identified as a cause
for the condition, but subsequent studies showed equivocal results which prompted researchers
to look at other potential etiologies. Further investigations into the disease revealed that
systemic inflammatory response induced by surgical trauma could actually trigger dysfunction
in the blood-brain barrier, which had a good correlation with clinical cognitive function
impairment.
It is suspected that peripheral macrophage infiltration, which was observed in other
scenarios of blood-brain-barrier degeneration, might play a part in the systemic immune
response after surgery. Thus, this study employs the used of transgenic CD68-EGFP mice with fluorescently tagged peripheral macrophages, in hopes of finding out whether infiltration of
peripheral macrophages occurs in systemic immune response triggered by surgery. Although
the results showed that there was no significant increased macrophage infiltration in systemic
immune response, it was found that certain areas in the hippocampus were subjected to
increased macrophage infiltration compared to the frontal cortex even in the absence of
systemic immune response, suggesting peripheral macrophage might also play a role in
physiological conditions.
|
Degree | Master of Research in Medicine |
Subject | Immune response Blood-brain barrier |
Dept/Program | Medicine |
Persistent Identifier | http://hdl.handle.net/10722/314659 |
DC Field | Value | Language |
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dc.contributor.author | Yan, Tim | - |
dc.contributor.author | 殷浩翔 | - |
dc.date.accessioned | 2022-07-22T06:48:20Z | - |
dc.date.available | 2022-07-22T06:48:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Yan, T. [殷浩翔]. (2022). Investigating the effects of systemic immune responses on the infiltration of peripheral macrophages into the brain. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. | - |
dc.identifier.uri | http://hdl.handle.net/10722/314659 | - |
dc.description.abstract | Postoperative cognitive dysfunction (POCD) is a complication occurring days to months after surgery causing deficits in memory, executive functions and other cognitive abilities. It is especially prevalent among the elderly, which makes it an increasingly important healthcare problem as population aging becomes progressively severe in Hong Kong. A lot of research has been conducted in hopes of uncovering the mechanisms behind POCD, with limited success. Anaesthesia used during surgery was first identified as a cause for the condition, but subsequent studies showed equivocal results which prompted researchers to look at other potential etiologies. Further investigations into the disease revealed that systemic inflammatory response induced by surgical trauma could actually trigger dysfunction in the blood-brain barrier, which had a good correlation with clinical cognitive function impairment. It is suspected that peripheral macrophage infiltration, which was observed in other scenarios of blood-brain-barrier degeneration, might play a part in the systemic immune response after surgery. Thus, this study employs the used of transgenic CD68-EGFP mice with fluorescently tagged peripheral macrophages, in hopes of finding out whether infiltration of peripheral macrophages occurs in systemic immune response triggered by surgery. Although the results showed that there was no significant increased macrophage infiltration in systemic immune response, it was found that certain areas in the hippocampus were subjected to increased macrophage infiltration compared to the frontal cortex even in the absence of systemic immune response, suggesting peripheral macrophage might also play a role in physiological conditions. | - |
dc.language | eng | - |
dc.publisher | The University of Hong Kong (Pokfulam, Hong Kong) | - |
dc.relation.ispartof | HKU Theses Online (HKUTO) | - |
dc.rights | The author retains all proprietary rights, (such as patent rights) and the right to use in future works. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.lcsh | Immune response | - |
dc.subject.lcsh | Blood-brain barrier | - |
dc.title | Investigating the effects of systemic immune responses on the infiltration of peripheral macrophages into the brain | - |
dc.type | PG_Thesis | - |
dc.description.thesisname | Master of Research in Medicine | - |
dc.description.thesislevel | Master | - |
dc.description.thesisdiscipline | Medicine | - |
dc.description.nature | published_or_final_version | - |
dc.date.hkucongregation | 2022 | - |
dc.identifier.mmsid | 991044566903703414 | - |