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Article: HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria

TitleHOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria
Authors
Wu, YishuoJiang, GuangliangZhang, NingLiu, ShenghuaLin, XiaolingPerschon, ChelseaZheng, S. LillyDing, QiangWang, XiangNa, RongSun, JishanXu, Jianfeng
KeywordsBladder cancer
Diagnosis
Methylation
Urinary biomarker
Issue Date2020
Citation
European Urology Focus, 2020, v. 6, n. 2, p. 284-291 How to Cite?
DOI: http://dx.doi.org/10.1016/j.euf.2018.09.016
AbstractUsing a strategy of three-level risk stratification, a combination methylation assay of HOXA9, PCDH17, POU4F2, and ONECUT2 resulted in a positive predictive value of 100% for predicting bladder cancer in Chinese patients with hematuria. With an estimated cancer prevalence of 10% in a general hematuria population, the assay would result in an overall negative predictive value of 98%. Over half of bladder cancer cases would be predicted accurately, and ∼60% of unnecessary cystoscopy could be spared.
Persistent Identifierhttp://hdl.handle.net/10722/314423
ISI Accession Number ID
WOS:000514857500020

 

DC FieldValueLanguage
dc.contributor.authorWu, Yishuo-
dc.contributor.authorJiang, Guangliang-
dc.contributor.authorZhang, Ning-
dc.contributor.authorLiu, Shenghua-
dc.contributor.authorLin, Xiaoling-
dc.contributor.authorPerschon, Chelsea-
dc.contributor.authorZheng, S. Lilly-
dc.contributor.authorDing, Qiang-
dc.contributor.authorWang, Xiang-
dc.contributor.authorNa, Rong-
dc.contributor.authorSun, Jishan-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:04:01Z-
dc.date.available2022-07-20T12:04:01Z-
dc.date.issued2020-
dc.identifier.citationEuropean Urology Focus, 2020, v. 6, n. 2, p. 284-291-
dc.identifier.urihttp://hdl.handle.net/10722/314423-
dc.description.abstractUsing a strategy of three-level risk stratification, a combination methylation assay of HOXA9, PCDH17, POU4F2, and ONECUT2 resulted in a positive predictive value of 100% for predicting bladder cancer in Chinese patients with hematuria. With an estimated cancer prevalence of 10% in a general hematuria population, the assay would result in an overall negative predictive value of 98%. Over half of bladder cancer cases would be predicted accurately, and ∼60% of unnecessary cystoscopy could be spared.-
dc.languageeng-
dc.relation.ispartofEuropean Urology Focus-
dc.subjectBladder cancer-
dc.subjectDiagnosis-
dc.subjectMethylation-
dc.subjectUrinary biomarker-
dc.titleHOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.euf.2018.09.016-
dc.identifier.pmid30309818-
dc.identifier.scopuseid_2-s2.0-85054439123-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage284-
dc.identifier.epage291-
dc.identifier.eissn2405-4569-
dc.identifier.isiWOS:000514857500020-

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