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Article: Association of sickle cell trait with risk and mortality of COVID-19: Results from the United Kingdom Biobank

TitleAssociation of sickle cell trait with risk and mortality of COVID-19: Results from the United Kingdom Biobank
Authors
Issue Date2021
Citation
American Journal of Tropical Medicine and Hygiene, 2021, v. 105, n. 2, p. 368-371 How to Cite?
AbstractSickle cell trait (SCT) carriers inherit one copy of the Glu6Val mutation in the hemoglobin gene and is particularly common in Black individuals (5–10%). Considering the roles of hemoglobin in immune responses and the higher risk for coronavirus disease (COVID-19) among Black individuals, we tested whether Black SCT carriers were at increased risk for COVID-19 infection and mortality according to the United Kingdom Biobank. Among Black individuals who were tested for COVID-19, we found similar infection rates among SCT carriers (14/72; 19.7%) and noncarriers (167/791; 21.1%), but higher COVID-19 mortality rates among SCT carriers (4/14; 28.6%) than among noncarriers (21/167; 12.6%) (odds ratio [OR], 3.04; 95% confidence interval [CI], 0.69–11.82; P 5 0.12). Notably, SCT carriers with preexisting diabetes had significantly higher COVID-19 mortality (4/4; 100%) than those without diabetes (0/10; 0%; (OR, 90.71; 95% CI, 5.66–infinite; P 5 0.0005). These findings suggest that Black SCT carriers with preexisting diabetes are at disproportionally higher risk for COVID-19 mortality. Confirmation by larger studies is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/314413
ISSN
2023 Impact Factor: 1.9
2023 SCImago Journal Rankings: 0.834
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorResurreccion, W. Kyle-
dc.contributor.authorHulsizer, Joseph-
dc.contributor.authorShi, Zhuqing-
dc.contributor.authorWei, Jun-
dc.contributor.authorWang, Chi Hsiung-
dc.contributor.authorNa, Rong-
dc.contributor.authorZheng, S. Lilly-
dc.contributor.authorStruve, Clay-
dc.contributor.authorHelfand, Brian T.-
dc.contributor.authorKhandekar, Janardan-
dc.contributor.authorBillings, Liana-
dc.contributor.authorCaplan, Michael S.-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:03:59Z-
dc.date.available2022-07-20T12:03:59Z-
dc.date.issued2021-
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene, 2021, v. 105, n. 2, p. 368-371-
dc.identifier.issn0002-9637-
dc.identifier.urihttp://hdl.handle.net/10722/314413-
dc.description.abstractSickle cell trait (SCT) carriers inherit one copy of the Glu6Val mutation in the hemoglobin gene and is particularly common in Black individuals (5–10%). Considering the roles of hemoglobin in immune responses and the higher risk for coronavirus disease (COVID-19) among Black individuals, we tested whether Black SCT carriers were at increased risk for COVID-19 infection and mortality according to the United Kingdom Biobank. Among Black individuals who were tested for COVID-19, we found similar infection rates among SCT carriers (14/72; 19.7%) and noncarriers (167/791; 21.1%), but higher COVID-19 mortality rates among SCT carriers (4/14; 28.6%) than among noncarriers (21/167; 12.6%) (odds ratio [OR], 3.04; 95% confidence interval [CI], 0.69–11.82; P 5 0.12). Notably, SCT carriers with preexisting diabetes had significantly higher COVID-19 mortality (4/4; 100%) than those without diabetes (0/10; 0%; (OR, 90.71; 95% CI, 5.66–infinite; P 5 0.0005). These findings suggest that Black SCT carriers with preexisting diabetes are at disproportionally higher risk for COVID-19 mortality. Confirmation by larger studies is warranted.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAssociation of sickle cell trait with risk and mortality of COVID-19: Results from the United Kingdom Biobank-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4269/ajtmh.20-1657-
dc.identifier.pmid34129519-
dc.identifier.pmcidPMC8437181-
dc.identifier.scopuseid_2-s2.0-85112768946-
dc.identifier.volume105-
dc.identifier.issue2-
dc.identifier.spage368-
dc.identifier.epage371-
dc.identifier.eissn1476-1645-
dc.identifier.isiWOS:000684573800016-

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