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Article: The influence of prostate volume on cancer detection in the Chinese population

TitleThe influence of prostate volume on cancer detection in the Chinese population
Authors
KeywordsChina
Prostate cancer
Prostate volume
Prostate-specific antigen
Issue Date2014
Citation
Asian Journal of Andrology, 2014, v. 16, n. 3, p. 482-486 How to Cite?
AbstractIn western populations, prostate volume (PV) has been proven to be one of the strongest predictors of detecting prostate cancer (PCa) in biopsies. We performed this study in a biopsy cohort, to evaluate associations among the prostate volume, prostate-specific antigen (PSA) and PCa detection in the Chinese population. Between the years, 2007-13, 1486 men underwent prostate biopsy at Huashan Hospital, Fudan University, Shanghai, China. The study population was divided into two groups for analysis according to total PSA (tPSA) range (4 ng ml-1 < tPSA ≤20 ng ml-1 and tPSA > 20 ng ml-1 ). PV, age, tPSA, digital rectal examination (DRE) and transrectal ultrasound (TRUS) results were also included in the analysis. Although the positive biopsy rates decreased in both tPSA range groups, the downtrend was more pronounced in the 4 ng ml-1 < tPSA ≤20 ng ml-1 group; therefore, we focused on 853 men in this group with increasing PV. In multivariate logistic regression analysis, only DRE was found to be associated with PCa in four PV groups (P < 0.05) and tPSA did not show a good predictive ability when PV exceeded 50 ml (P > 0.05). Further, it may suggest that with increasing PV, the cancer detection rate decreased in men with different tPSA, DRE and TRUS nodule statuses (all P values for trends were <0.001). Our study indicates that in tPSA ranging from 4 to 20 ng ml -1 , the use of PV ranges of 0-35 ml, 35-50 ml and > 50 ml might be taken into consideration for the biopsy decision-making in the Chinese population. © 2014 AJA, SIMM & SJTU.
Persistent Identifierhttp://hdl.handle.net/10722/314381
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.689
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, Yi Shuo-
dc.contributor.authorNa, Rong-
dc.contributor.authorXu, Jian Feng-
dc.contributor.authorBai, Pei De-
dc.contributor.authorJiang, Hao Wen-
dc.contributor.authorDing, Qiang-
dc.date.accessioned2022-07-20T12:03:51Z-
dc.date.available2022-07-20T12:03:51Z-
dc.date.issued2014-
dc.identifier.citationAsian Journal of Andrology, 2014, v. 16, n. 3, p. 482-486-
dc.identifier.issn1008-682X-
dc.identifier.urihttp://hdl.handle.net/10722/314381-
dc.description.abstractIn western populations, prostate volume (PV) has been proven to be one of the strongest predictors of detecting prostate cancer (PCa) in biopsies. We performed this study in a biopsy cohort, to evaluate associations among the prostate volume, prostate-specific antigen (PSA) and PCa detection in the Chinese population. Between the years, 2007-13, 1486 men underwent prostate biopsy at Huashan Hospital, Fudan University, Shanghai, China. The study population was divided into two groups for analysis according to total PSA (tPSA) range (4 ng ml-1 < tPSA ≤20 ng ml-1 and tPSA > 20 ng ml-1 ). PV, age, tPSA, digital rectal examination (DRE) and transrectal ultrasound (TRUS) results were also included in the analysis. Although the positive biopsy rates decreased in both tPSA range groups, the downtrend was more pronounced in the 4 ng ml-1 < tPSA ≤20 ng ml-1 group; therefore, we focused on 853 men in this group with increasing PV. In multivariate logistic regression analysis, only DRE was found to be associated with PCa in four PV groups (P < 0.05) and tPSA did not show a good predictive ability when PV exceeded 50 ml (P > 0.05). Further, it may suggest that with increasing PV, the cancer detection rate decreased in men with different tPSA, DRE and TRUS nodule statuses (all P values for trends were <0.001). Our study indicates that in tPSA ranging from 4 to 20 ng ml -1 , the use of PV ranges of 0-35 ml, 35-50 ml and > 50 ml might be taken into consideration for the biopsy decision-making in the Chinese population. © 2014 AJA, SIMM & SJTU.-
dc.languageeng-
dc.relation.ispartofAsian Journal of Andrology-
dc.subjectChina-
dc.subjectProstate cancer-
dc.subjectProstate volume-
dc.subjectProstate-specific antigen-
dc.titleThe influence of prostate volume on cancer detection in the Chinese population-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4103/1008-682X.125905-
dc.identifier.pmid24625884-
dc.identifier.pmcidPMC4023383-
dc.identifier.scopuseid_2-s2.0-84900472342-
dc.identifier.volume16-
dc.identifier.issue3-
dc.identifier.spage482-
dc.identifier.epage486-
dc.identifier.eissn1745-7262-
dc.identifier.isiWOS:000336082200029-

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