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Article: LILRA3 is associated with benign prostatic hyperplasia risk in a Chinese population

TitleLILRA3 is associated with benign prostatic hyperplasia risk in a Chinese population
Authors
KeywordsBenign prostatic hyperplasia (BPH)
Chinese
Inflammation
LILRA3
Single nucleotide polymorphism (SNP)
Issue Date2013
Citation
International Journal of Molecular Sciences, 2013, v. 14, n. 5, p. 8832-8840 How to Cite?
AbstractA recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele "C" had increased risk for BPH (OR = 1.34, 95% CI: 1.09-1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06-2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Persistent Identifierhttp://hdl.handle.net/10722/314375
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiao, Yang-
dc.contributor.authorWang, Li-
dc.contributor.authorGu, Xin-
dc.contributor.authorTao, Sha-
dc.contributor.authorTian, Lu-
dc.contributor.authorNa, Rong-
dc.contributor.authorChen, Zhuo-
dc.contributor.authorKang, Jian-
dc.contributor.authorZheng, Siqun L.-
dc.contributor.authorXu, Jianfeng-
dc.contributor.authorSun, Jielin-
dc.contributor.authorQi, Jun-
dc.date.accessioned2022-07-20T12:03:48Z-
dc.date.available2022-07-20T12:03:48Z-
dc.date.issued2013-
dc.identifier.citationInternational Journal of Molecular Sciences, 2013, v. 14, n. 5, p. 8832-8840-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/314375-
dc.description.abstractA recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele "C" had increased risk for BPH (OR = 1.34, 95% CI: 1.09-1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06-2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results. © 2013 by the authors; licensee MDPI, Basel, Switzerland.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBenign prostatic hyperplasia (BPH)-
dc.subjectChinese-
dc.subjectInflammation-
dc.subjectLILRA3-
dc.subjectSingle nucleotide polymorphism (SNP)-
dc.titleLILRA3 is associated with benign prostatic hyperplasia risk in a Chinese population-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms14058832-
dc.identifier.pmid23615473-
dc.identifier.pmcidPMC3676759-
dc.identifier.scopuseid_2-s2.0-84876923599-
dc.identifier.volume14-
dc.identifier.issue5-
dc.identifier.spage8832-
dc.identifier.epage8840-
dc.identifier.eissn1422-0067-
dc.identifier.isiWOS:000319441500010-

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