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Article: Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

TitleGenome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4
Authors
Issue Date2012
Citation
Nature Genetics, 2012, v. 44, n. 11, p. 1231-1235 How to Cite?
AbstractProstate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10-14) and 19q13.4 (rs103294, P = 5.34 × 10-16) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10-4). These findings may advance the understanding of genetic susceptibility to prostate cancer. © 2012 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/314343
ISSN
2023 Impact Factor: 31.7
2023 SCImago Journal Rankings: 17.300
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Jianfeng-
dc.contributor.authorMo, Zengnan-
dc.contributor.authorYe, Dingwei-
dc.contributor.authorWang, Meilin-
dc.contributor.authorLiu, Fang-
dc.contributor.authorJin, Guangfu-
dc.contributor.authorXu, Chuanliang-
dc.contributor.authorWang, Xiang-
dc.contributor.authorShao, Qiang-
dc.contributor.authorChen, Zhiwen-
dc.contributor.authorTao, Zhihua-
dc.contributor.authorQi, Jun-
dc.contributor.authorZhou, Fangjian-
dc.contributor.authorWang, Zhong-
dc.contributor.authorFu, Yaowen-
dc.contributor.authorHe, Dalin-
dc.contributor.authorWei, Qiang-
dc.contributor.authorGuo, Jianming-
dc.contributor.authorWu, Denglong-
dc.contributor.authorGao, Xin-
dc.contributor.authorYuan, Jianlin-
dc.contributor.authorWang, Gongxian-
dc.contributor.authorXu, Yong-
dc.contributor.authorWang, Guozeng-
dc.contributor.authorYao, Haijun-
dc.contributor.authorDong, Pei-
dc.contributor.authorJiao, Yang-
dc.contributor.authorShen, Mo-
dc.contributor.authorYang, Jin-
dc.contributor.authorOu-Yang, Jun-
dc.contributor.authorJiang, Haowen-
dc.contributor.authorZhu, Yao-
dc.contributor.authorRen, Shancheng-
dc.contributor.authorZhang, Zhengdong-
dc.contributor.authorYin, Changjun-
dc.contributor.authorGao, Xu-
dc.contributor.authorDai, Bo-
dc.contributor.authorHu, Zhibin-
dc.contributor.authorYang, Yajun-
dc.contributor.authorWu, Qijun-
dc.contributor.authorChen, Hongyan-
dc.contributor.authorPeng, Peng-
dc.contributor.authorZheng, Ying-
dc.contributor.authorZheng, Xiaodong-
dc.contributor.authorXiang, Yongbing-
dc.contributor.authorLong, Jirong-
dc.contributor.authorGong, Jian-
dc.contributor.authorNa, Rong-
dc.contributor.authorLin, Xiaoling-
dc.contributor.authorYu, Hongjie-
dc.contributor.authorWeng, Zhong-
dc.contributor.authorTao, Sha-
dc.contributor.authorFeng, Junjie-
dc.contributor.authorSun, Jishan-
dc.contributor.authorLiu, Wennuan-
dc.contributor.authorHsing, Ann-
dc.contributor.authorRao, Jianyu-
dc.contributor.authorDing, Qiang-
dc.contributor.authorWikland, Fredirik-
dc.contributor.authorGronberg, Henrik-
dc.contributor.authorShu, Xiao Ou-
dc.contributor.authorZheng, Wei-
dc.contributor.authorShen, Hongbing-
dc.contributor.authorJin, Li-
dc.contributor.authorShi, Rong-
dc.contributor.authorLu, Daru-
dc.contributor.authorZhang, Xuejun-
dc.contributor.authorSun, Jielin-
dc.contributor.authorLilly Zheng, S.-
dc.contributor.authorSun, Yinghao-
dc.date.accessioned2022-07-20T12:03:41Z-
dc.date.available2022-07-20T12:03:41Z-
dc.date.issued2012-
dc.identifier.citationNature Genetics, 2012, v. 44, n. 11, p. 1231-1235-
dc.identifier.issn1061-4036-
dc.identifier.urihttp://hdl.handle.net/10722/314343-
dc.description.abstractProstate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10-14) and 19q13.4 (rs103294, P = 5.34 × 10-16) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10-4). These findings may advance the understanding of genetic susceptibility to prostate cancer. © 2012 Nature America, Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNature Genetics-
dc.titleGenome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.2424-
dc.identifier.pmid23023329-
dc.identifier.pmcidPMC4116636-
dc.identifier.scopuseid_2-s2.0-84868206960-
dc.identifier.volume44-
dc.identifier.issue11-
dc.identifier.spage1231-
dc.identifier.epage1235-
dc.identifier.eissn1546-1718-
dc.identifier.isiWOS:000310495800015-

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