File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Epidemiology of paediatric Middle East respiratory syndrome coronavirus and implications for the control of coronavirus virus disease 2019

TitleEpidemiology of paediatric Middle East respiratory syndrome coronavirus and implications for the control of coronavirus virus disease 2019
Authors
Keywordsasymptomatic infections
communicable diseases
COVID-19
emerging
Middle East respiratory syndrome coronavirus
Saudi Arabia
Issue Date2020
Citation
Journal of paediatrics and child health, 2020, v. 56 n. 10, p. 1561-1564 How to Cite?
AbstractAim: To compare the clinical features of Middle East respiratory syndrome coronavirus (MERS-CoV) infection between paediatric and adult cases. Methods: Using multiple public data sources, we created an enhanced open-source surveillance dataset of all MERS-CoV cases between 20 September 2012 and 31 December 2018 in Saudi Arabia including available risk factor data. Results: Of the 1791 cases of MERS-CoV identified, 30 cases (1.7%) were aged under 18 years and 1725 cases (96.3%) were aged 18 years and over. Three paediatric cases were fatal, aged 0, 2 and 15 years. The odds of asymptomatic MERS-CoV infection among cases under 18 years (n = 10/23; 44%) was significantly higher (odds ratio (OR) = 4.98; 95% confidence interval (CI): 2.15–11.51; P = 0.001) compared to adults (n = 199/1487; 13%). The odds of hospitalisation were significantly lower (OR = 0.17; 95% CI: 0.08–0.39; P < 0.001) among cases under 18 years (n = 12/24; 50%) compared to adults (n = 1231/1443; 85%). Children were more likely to have a known source of exposure compared to adults (OR = 2.68; 95% CI: 1.29–5.56; P = 0.008). Conclusions: Clinically severe illness is less common in children, although death can occur, and the proportion of paediatric cases (1.7%) is similar to that reported for COVID-19. Age-specific differences in the clinical presentation of MERS-CoV cases could have implications for transmission for other betacoronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children may be at risk within the household with an infected adult. More studies are required on the role of children in transmission of betacoronaviruses.
Persistent Identifierhttp://hdl.handle.net/10722/314320
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.499
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMacIntyre, CR-
dc.contributor.authorChen, X-
dc.contributor.authorAdam, DC-
dc.contributor.authorChughtai, AA-
dc.date.accessioned2022-07-18T06:15:51Z-
dc.date.available2022-07-18T06:15:51Z-
dc.date.issued2020-
dc.identifier.citationJournal of paediatrics and child health, 2020, v. 56 n. 10, p. 1561-1564-
dc.identifier.issn1034-4810-
dc.identifier.urihttp://hdl.handle.net/10722/314320-
dc.description.abstractAim: To compare the clinical features of Middle East respiratory syndrome coronavirus (MERS-CoV) infection between paediatric and adult cases. Methods: Using multiple public data sources, we created an enhanced open-source surveillance dataset of all MERS-CoV cases between 20 September 2012 and 31 December 2018 in Saudi Arabia including available risk factor data. Results: Of the 1791 cases of MERS-CoV identified, 30 cases (1.7%) were aged under 18 years and 1725 cases (96.3%) were aged 18 years and over. Three paediatric cases were fatal, aged 0, 2 and 15 years. The odds of asymptomatic MERS-CoV infection among cases under 18 years (n = 10/23; 44%) was significantly higher (odds ratio (OR) = 4.98; 95% confidence interval (CI): 2.15–11.51; P = 0.001) compared to adults (n = 199/1487; 13%). The odds of hospitalisation were significantly lower (OR = 0.17; 95% CI: 0.08–0.39; P < 0.001) among cases under 18 years (n = 12/24; 50%) compared to adults (n = 1231/1443; 85%). Children were more likely to have a known source of exposure compared to adults (OR = 2.68; 95% CI: 1.29–5.56; P = 0.008). Conclusions: Clinically severe illness is less common in children, although death can occur, and the proportion of paediatric cases (1.7%) is similar to that reported for COVID-19. Age-specific differences in the clinical presentation of MERS-CoV cases could have implications for transmission for other betacoronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Children may be at risk within the household with an infected adult. More studies are required on the role of children in transmission of betacoronaviruses.-
dc.languageeng-
dc.relation.ispartofJournal of paediatrics and child health-
dc.subjectasymptomatic infections-
dc.subjectcommunicable diseases-
dc.subjectCOVID-19-
dc.subjectemerging-
dc.subjectMiddle East respiratory syndrome coronavirus-
dc.subjectSaudi Arabia-
dc.titleEpidemiology of paediatric Middle East respiratory syndrome coronavirus and implications for the control of coronavirus virus disease 2019-
dc.typeArticle-
dc.identifier.emailAdam, DC: dcadam@hku.hk-
dc.identifier.doi10.1111/jpc.15014-
dc.identifier.pmid32729192-
dc.identifier.pmcidPMC7689819-
dc.identifier.scopuseid_2-s2.0-85088780900-
dc.identifier.hkuros334166-
dc.identifier.volume56-
dc.identifier.issue10-
dc.identifier.spage1561-
dc.identifier.epage1564-
dc.identifier.isiWOS:000553409600001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats