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- Publisher Website: 10.1021/acsomega.1c06880
- WOS: WOS:000820364900001
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Article: Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity
Title | Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity |
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Authors | |
Issue Date | 2022 |
Citation | ACS Omega, 2022, v. 7 n. 22, p. 18238-18246 How to Cite? |
Abstract | Previous reports indicated the low stability of severe actute respiratory syndrome coronovirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonporous solids of the same chemistry. Through comparing pairs of solids with very similar chemistry, we find that porosity is important: porous glass has a much lower infectivity than nonporous glass. However, porosity is not sufficient to lower infectivity; permeability, which is the ability of a liquid to move through a material, is the important parameter. We show this by comparing a pair of porous CuO coatings where the pores are accessible in one case and inaccessible in the other case. When the pores are inaccessible, the infectivity remains similar to that for nonporous solids. Thus, for both glass and CuO, it is the access to porosity that decreases the infectivity of extracted liquid droplets. Having established the importance of permeability, there is the open question of the mechanism of changing the infectivity of SARS-CoV-2. Several hypotheses are possible, such as increasing the difficulty of extracting the virus from the solid, changing the drying time, increasing the surface area of active ingredient, etc. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) measurements show that less viral DNA is extracted from a permeable surface, suggesting that the virus becomes trapped in the pores. Finally, we consider the effect of drying. We show that permeability and the water contact angle on the solid have effects on the drying time of a contaminated droplet, which may in turn affect infectivity. |
Persistent Identifier | http://hdl.handle.net/10722/314239 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hosseini, MOHSEN | - |
dc.contributor.author | Poon, LML | - |
dc.contributor.author | Chin, WH | - |
dc.contributor.author | Ducker, WILLIAM A | - |
dc.date.accessioned | 2022-07-18T06:14:21Z | - |
dc.date.available | 2022-07-18T06:14:21Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | ACS Omega, 2022, v. 7 n. 22, p. 18238-18246 | - |
dc.identifier.uri | http://hdl.handle.net/10722/314239 | - |
dc.description.abstract | Previous reports indicated the low stability of severe actute respiratory syndrome coronovirus 2 (SARS-CoV-2) on various porous surfaces, but the role of porosity was unclear because there was no direct comparison between porous and nonporous solids of the same chemistry. Through comparing pairs of solids with very similar chemistry, we find that porosity is important: porous glass has a much lower infectivity than nonporous glass. However, porosity is not sufficient to lower infectivity; permeability, which is the ability of a liquid to move through a material, is the important parameter. We show this by comparing a pair of porous CuO coatings where the pores are accessible in one case and inaccessible in the other case. When the pores are inaccessible, the infectivity remains similar to that for nonporous solids. Thus, for both glass and CuO, it is the access to porosity that decreases the infectivity of extracted liquid droplets. Having established the importance of permeability, there is the open question of the mechanism of changing the infectivity of SARS-CoV-2. Several hypotheses are possible, such as increasing the difficulty of extracting the virus from the solid, changing the drying time, increasing the surface area of active ingredient, etc. Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) measurements show that less viral DNA is extracted from a permeable surface, suggesting that the virus becomes trapped in the pores. Finally, we consider the effect of drying. We show that permeability and the water contact angle on the solid have effects on the drying time of a contaminated droplet, which may in turn affect infectivity. | - |
dc.language | eng | - |
dc.relation.ispartof | ACS Omega | - |
dc.title | Effect of Surface Porosity on SARS-CoV-2 Fomite Infectivity | - |
dc.type | Article | - |
dc.identifier.email | Poon, LML: llmpoon@hkucc.hku.hk | - |
dc.identifier.email | Chin, WH: alexchin@hku.hk | - |
dc.identifier.authority | Poon, LML=rp00484 | - |
dc.identifier.authority | Chin, WH=rp02345 | - |
dc.identifier.doi | 10.1021/acsomega.1c06880 | - |
dc.identifier.hkuros | 334281 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 22 | - |
dc.identifier.spage | 18238 | - |
dc.identifier.epage | 18246 | - |
dc.identifier.isi | WOS:000820364900001 | - |