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Article: An Autonomous Diurnal Sweat Sampling Patch for Biomarker Data Analytics

TitleAn Autonomous Diurnal Sweat Sampling Patch for Biomarker Data Analytics
Authors
KeywordsBiomarker data analytics
health monitoring
iontophoresis
longitudinal sweat sampling
personalized and precision medicine
sweat analysis
wearable electronics
Issue Date2020
Citation
Journal of Microelectromechanical Systems, 2020, v. 29, n. 5, p. 1106-1108 How to Cite?
AbstractWearable sweat analysis possesses significant potential for transforming personalized and precision medicine, by capturing the longitudinal profiles of a broad spectrum of biomarker molecules that are informative of our body's dynamic chemistry. However, the lack of established physiological criteria to provide personalized feedback, based on sweat biomarker readings, has prevented the translation of wearable sweat-based bioanalytical technologies into health and wellness monitoring applications. Accordingly, scalable sweat sampling tools are required to facilitate large-scale and longitudinal clinical studies focusing on interpreting sweat biomarker readings. However, conventional sweat induction-collection tools are bulky and require multi-step and manual operations. Accordingly, here, we devise a sweat sampling patch, which can be deployed for autonomous diurnal sweat induction-collection. The core of this patch is an addressable array of miniaturized and coupled iontophoresis/microfluidic interfaces that can be activated on-demand or at scheduled time-points to induce/collect sufficient sweat samples for analysis. The iontophoresis interface was designed following an introduced design space centering on sufficient sweat secretory agonist delivery at safe current levels. The microfluidic interface was fabricated following a simple, rapid, and low-cost fabrication scheme. To achieve autonomous operation, these interfaces were extended into an array format and coupled with a custom-developed flexible and wireless circuit board. To inform utility, periodically induced/collected sweat samples of an individual were analyzed in relation to meal intake. [2020-0194].
Persistent Identifierhttp://hdl.handle.net/10722/314026
ISSN
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.744
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHojaiji, Hannaneh-
dc.contributor.authorZhao, Yichao-
dc.contributor.authorLin, Shuyu-
dc.contributor.authorGong, Max C.-
dc.contributor.authorMallajosyula, Mudith-
dc.contributor.authorLin, Haisong-
dc.contributor.authorHojaiji, Amir M.-
dc.contributor.authorMadni, Asad M.-
dc.contributor.authorEmaminejad, Sam-
dc.date.accessioned2022-07-06T11:28:54Z-
dc.date.available2022-07-06T11:28:54Z-
dc.date.issued2020-
dc.identifier.citationJournal of Microelectromechanical Systems, 2020, v. 29, n. 5, p. 1106-1108-
dc.identifier.issn1057-7157-
dc.identifier.urihttp://hdl.handle.net/10722/314026-
dc.description.abstractWearable sweat analysis possesses significant potential for transforming personalized and precision medicine, by capturing the longitudinal profiles of a broad spectrum of biomarker molecules that are informative of our body's dynamic chemistry. However, the lack of established physiological criteria to provide personalized feedback, based on sweat biomarker readings, has prevented the translation of wearable sweat-based bioanalytical technologies into health and wellness monitoring applications. Accordingly, scalable sweat sampling tools are required to facilitate large-scale and longitudinal clinical studies focusing on interpreting sweat biomarker readings. However, conventional sweat induction-collection tools are bulky and require multi-step and manual operations. Accordingly, here, we devise a sweat sampling patch, which can be deployed for autonomous diurnal sweat induction-collection. The core of this patch is an addressable array of miniaturized and coupled iontophoresis/microfluidic interfaces that can be activated on-demand or at scheduled time-points to induce/collect sufficient sweat samples for analysis. The iontophoresis interface was designed following an introduced design space centering on sufficient sweat secretory agonist delivery at safe current levels. The microfluidic interface was fabricated following a simple, rapid, and low-cost fabrication scheme. To achieve autonomous operation, these interfaces were extended into an array format and coupled with a custom-developed flexible and wireless circuit board. To inform utility, periodically induced/collected sweat samples of an individual were analyzed in relation to meal intake. [2020-0194].-
dc.languageeng-
dc.relation.ispartofJournal of Microelectromechanical Systems-
dc.subjectBiomarker data analytics-
dc.subjecthealth monitoring-
dc.subjectiontophoresis-
dc.subjectlongitudinal sweat sampling-
dc.subjectpersonalized and precision medicine-
dc.subjectsweat analysis-
dc.subjectwearable electronics-
dc.titleAn Autonomous Diurnal Sweat Sampling Patch for Biomarker Data Analytics-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1109/JMEMS.2020.3010537-
dc.identifier.scopuseid_2-s2.0-85092613968-
dc.identifier.volume29-
dc.identifier.issue5-
dc.identifier.spage1106-
dc.identifier.epage1108-
dc.identifier.eissn1941-0158-
dc.identifier.isiWOS:000576466500080-

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