File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics

TitleNoninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics
Authors
Issue Date2020
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2020, v. 117, n. 32, p. 19017-19025 How to Cite?
AbstractTo achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large scale to monitor the individuals drug transcourse profiles (semi) continuously and longitudinally. To this end, voltammetry-based sensing modalities are suitable, as in principle they can detect and quantify electroactive drugs on the basis of the target s redox signature. However, the target s redox signature in complex biofluid matrices can be confounded by the immediate biofouling effects and distorted/buried by the interfering voltammetric responses of endogenous electroactive species. Here, we devise a wearable voltammetric sensor development strategy centering on engineering the molecule-surface interactions to simultaneously mitigate biofouling and create an undistorted potential window within which the target drug s voltammetric response is dominant and interference is eliminated. To inform its clinical utility, our strategy was adopted to track the temporal profile of circulating acetaminophen (a widely used analgesic and antipyretic) in saliva and sweat, using a surface-modified boron-doped diamond sensing interface (cross-validated with laboratory-based assays, R2 ∼ 0.94). Through integration of the engineered sensing interface within a custom-developed smartwatch, and augmentation with a dedicated analytical framework (for redox peak extraction), we realized a wearable solution to seamlessly render drug readouts with minute-level temporal resolution. Leveraging this solution, we demonstrated the pharmacokinetic correlation and significance of sweat readings.
Persistent Identifierhttp://hdl.handle.net/10722/314001
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Shuyu-
dc.contributor.authorYu, Wenzhuo-
dc.contributor.authorWang, Bo-
dc.contributor.authorZhao, Yichao-
dc.contributor.authorEn, Ke-
dc.contributor.authorZhu, Jialun-
dc.contributor.authorCheng, Xuanbing-
dc.contributor.authorZhou, Crystal-
dc.contributor.authorLin, Haisong-
dc.contributor.authorWang, Zhaoqing-
dc.contributor.authorHojaiji, Hannaneh-
dc.contributor.authorYeung, Christopher-
dc.contributor.authorMilla, Carlos-
dc.contributor.authorDavis, Ronald W.-
dc.date.accessioned2022-07-06T11:28:48Z-
dc.date.available2022-07-06T11:28:48Z-
dc.date.issued2020-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2020, v. 117, n. 32, p. 19017-19025-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/314001-
dc.description.abstractTo achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large scale to monitor the individuals drug transcourse profiles (semi) continuously and longitudinally. To this end, voltammetry-based sensing modalities are suitable, as in principle they can detect and quantify electroactive drugs on the basis of the target s redox signature. However, the target s redox signature in complex biofluid matrices can be confounded by the immediate biofouling effects and distorted/buried by the interfering voltammetric responses of endogenous electroactive species. Here, we devise a wearable voltammetric sensor development strategy centering on engineering the molecule-surface interactions to simultaneously mitigate biofouling and create an undistorted potential window within which the target drug s voltammetric response is dominant and interference is eliminated. To inform its clinical utility, our strategy was adopted to track the temporal profile of circulating acetaminophen (a widely used analgesic and antipyretic) in saliva and sweat, using a surface-modified boron-doped diamond sensing interface (cross-validated with laboratory-based assays, R2 ∼ 0.94). Through integration of the engineered sensing interface within a custom-developed smartwatch, and augmentation with a dedicated analytical framework (for redox peak extraction), we realized a wearable solution to seamlessly render drug readouts with minute-level temporal resolution. Leveraging this solution, we demonstrated the pharmacokinetic correlation and significance of sweat readings.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.titleNoninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.2009979117-
dc.identifier.pmid32719130-
dc.identifier.pmcidPMC7431025-
dc.identifier.scopuseid_2-s2.0-85089615171-
dc.identifier.volume117-
dc.identifier.issue32-
dc.identifier.spage19017-
dc.identifier.epage19025-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000561789200023-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats