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Article: A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery

TitleA 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery
Authors
Issue Date2019
Citation
Biomicrofluidics, 2019, v. 13, n. 6, article no. 064125 How to Cite?
AbstractEmbedding microfluidic architectures with microneedles enables fluid management capabilities that present new degrees of freedom for transdermal drug delivery. To this end, fabrication schemes that can simultaneously create and integrate complex millimeter/centimeter-long microfluidic structures and micrometer-scale microneedle features are necessary. Accordingly, three-dimensional (3D) printing techniques are suitable candidates because they allow the rapid realization of customizable yet intricate microfluidic and microneedle features. However, previously reported 3D-printing approaches utilized costly instrumentation that lacked the desired versatility to print both features in a single step and the throughput to render components within distinct length-scales. Here, for the first time in literature, we devise a fabrication scheme to create hollow microneedles interfaced with microfluidic structures in a single step. Our method utilizes stereolithography 3D-printing and pushes its boundaries (achieving print resolutions below the full width half maximum laser spot size resolution) to create complex architectures with lower cost and higher print speed and throughput than previously reported methods. To demonstrate a potential application, a microfluidic-enabled microneedle architecture was printed to render hydrodynamic mixing and transdermal drug delivery within a single device. The presented architectures can be adopted in future biomedical devices to facilitate new modes of operations for transdermal drug delivery applications such as combinational therapy for preclinical testing of biologic treatments.
Persistent Identifierhttp://hdl.handle.net/10722/313982
ISSN
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.516
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYeung, Christopher-
dc.contributor.authorChen, Shawnus-
dc.contributor.authorKing, Brian-
dc.contributor.authorLin, Haisong-
dc.contributor.authorKing, Kimber-
dc.contributor.authorAkhtar, Farooq-
dc.contributor.authorDiaz, Gustavo-
dc.contributor.authorWang, Bo-
dc.contributor.authorZhu, Jixiang-
dc.contributor.authorSun, Wujin-
dc.contributor.authorKhademhosseini, Ali-
dc.contributor.authorEmaminejad, Sam-
dc.date.accessioned2022-07-06T11:28:42Z-
dc.date.available2022-07-06T11:28:42Z-
dc.date.issued2019-
dc.identifier.citationBiomicrofluidics, 2019, v. 13, n. 6, article no. 064125-
dc.identifier.issn1932-1058-
dc.identifier.urihttp://hdl.handle.net/10722/313982-
dc.description.abstractEmbedding microfluidic architectures with microneedles enables fluid management capabilities that present new degrees of freedom for transdermal drug delivery. To this end, fabrication schemes that can simultaneously create and integrate complex millimeter/centimeter-long microfluidic structures and micrometer-scale microneedle features are necessary. Accordingly, three-dimensional (3D) printing techniques are suitable candidates because they allow the rapid realization of customizable yet intricate microfluidic and microneedle features. However, previously reported 3D-printing approaches utilized costly instrumentation that lacked the desired versatility to print both features in a single step and the throughput to render components within distinct length-scales. Here, for the first time in literature, we devise a fabrication scheme to create hollow microneedles interfaced with microfluidic structures in a single step. Our method utilizes stereolithography 3D-printing and pushes its boundaries (achieving print resolutions below the full width half maximum laser spot size resolution) to create complex architectures with lower cost and higher print speed and throughput than previously reported methods. To demonstrate a potential application, a microfluidic-enabled microneedle architecture was printed to render hydrodynamic mixing and transdermal drug delivery within a single device. The presented architectures can be adopted in future biomedical devices to facilitate new modes of operations for transdermal drug delivery applications such as combinational therapy for preclinical testing of biologic treatments.-
dc.languageeng-
dc.relation.ispartofBiomicrofluidics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1063/1.5127778-
dc.identifier.scopuseid_2-s2.0-85076639969-
dc.identifier.volume13-
dc.identifier.issue6-
dc.identifier.spagearticle no. 064125-
dc.identifier.epagearticle no. 064125-
dc.identifier.isiWOS:000505984000027-

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