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Article: A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

TitleA Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
Authors
Keywordsbrain tumors
circulating tumor cells
medulloblastoma
metastases
pediatric cancer
Issue Date2018
Citation
Cell, 2018, v. 172, n. 5, p. 1050-1062.e14 How to Cite?
AbstractWhile the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems. Medulloblastoma metastases are found almost exclusively on the leptomeningeal surface of the brain and spinal cord; dissemination is therefore thought to occur through shedding of primary tumor cells into the cerebrospinal fluid followed by distal re-implantation on the leptomeninges. We present evidence for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and demonstrate in vivo, through flank xenografting and parabiosis, that medulloblastoma CTCs can spread through the blood to the leptomeningeal space to form leptomeningeal metastases. Medulloblastoma leptomeningeal metastases express high levels of the chemokine CCL2, and expression of CCL2 in medulloblastoma in vivo is sufficient to drive leptomeningeal dissemination. Hematogenous dissemination of medulloblastoma offers a new opportunity to diagnose and treat lethal disseminated medulloblastoma. In addition to disseminating through the cerebrospinal fluid, medulloblastoma can metastasize through circulating tumor cells in the blood, thereby providing a different angle for clinical diagnosis and treatment development.
Persistent Identifierhttp://hdl.handle.net/10722/313977
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
PubMed Central ID
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorGarzia, Livia-
dc.contributor.authorKijima, Noriyuki-
dc.contributor.authorMorrissy, A. Sorana-
dc.contributor.authorDe Antonellis, Pasqualino-
dc.contributor.authorGuerreiro-Stucklin, Ana-
dc.contributor.authorHolgado, Borja L.-
dc.contributor.authorWu, Xiaochong-
dc.contributor.authorWang, Xin-
dc.contributor.authorParsons, Michael-
dc.contributor.authorZayne, Kory-
dc.contributor.authorManno, Alex-
dc.contributor.authorKuzan-Fischer, Claudia-
dc.contributor.authorNor, Carolina-
dc.contributor.authorDonovan, Laura K.-
dc.contributor.authorLiu, Jessica-
dc.contributor.authorQin, Lei-
dc.contributor.authorGarancher, Alexandra-
dc.contributor.authorLiu, Kun Wei-
dc.contributor.authorMansouri, Sheila-
dc.contributor.authorLuu, Betty-
dc.contributor.authorThompson, Yuan Yao-
dc.contributor.authorRamaswamy, Vijay-
dc.contributor.authorPeacock, John-
dc.contributor.authorFarooq, Hamza-
dc.contributor.authorSkowron, Patryk-
dc.contributor.authorShih, David J.H.-
dc.contributor.authorLi, Angela-
dc.contributor.authorEnsan, Sherine-
dc.contributor.authorRobbins, Clinton S.-
dc.contributor.authorCybulsky, Myron-
dc.contributor.authorMitra, Siddhartha-
dc.contributor.authorMa, Yussanne-
dc.contributor.authorMoore, Richard-
dc.contributor.authorMungall, Andy-
dc.contributor.authorCho, Yoon Jae-
dc.contributor.authorWeiss, William A.-
dc.contributor.authorChan, Jennifer A.-
dc.contributor.authorHawkins, Cynthia E.-
dc.contributor.authorMassimino, Maura-
dc.contributor.authorJabado, Nada-
dc.contributor.authorZapotocky, Michal-
dc.contributor.authorSumerauer, David-
dc.contributor.authorBouffet, Eric-
dc.contributor.authorDirks, Peter-
dc.contributor.authorTabori, Uri-
dc.contributor.authorSorensen, Poul H.B.-
dc.contributor.authorBrastianos, Priscilla K.-
dc.contributor.authorAldape, Kenneth-
dc.contributor.authorJones, Steven J.M.-
dc.contributor.authorMarra, Marco A.-
dc.contributor.authorWoodgett, James R.-
dc.contributor.authorWechsler-Reya, Robert J.-
dc.contributor.authorFults, Daniel W.-
dc.contributor.authorTaylor, Michael D.-
dc.date.accessioned2022-07-06T11:28:41Z-
dc.date.available2022-07-06T11:28:41Z-
dc.date.issued2018-
dc.identifier.citationCell, 2018, v. 172, n. 5, p. 1050-1062.e14-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/313977-
dc.description.abstractWhile the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples and model systems. Medulloblastoma metastases are found almost exclusively on the leptomeningeal surface of the brain and spinal cord; dissemination is therefore thought to occur through shedding of primary tumor cells into the cerebrospinal fluid followed by distal re-implantation on the leptomeninges. We present evidence for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and demonstrate in vivo, through flank xenografting and parabiosis, that medulloblastoma CTCs can spread through the blood to the leptomeningeal space to form leptomeningeal metastases. Medulloblastoma leptomeningeal metastases express high levels of the chemokine CCL2, and expression of CCL2 in medulloblastoma in vivo is sufficient to drive leptomeningeal dissemination. Hematogenous dissemination of medulloblastoma offers a new opportunity to diagnose and treat lethal disseminated medulloblastoma. In addition to disseminating through the cerebrospinal fluid, medulloblastoma can metastasize through circulating tumor cells in the blood, thereby providing a different angle for clinical diagnosis and treatment development.-
dc.languageeng-
dc.relation.ispartofCell-
dc.subjectbrain tumors-
dc.subjectcirculating tumor cells-
dc.subjectmedulloblastoma-
dc.subjectmetastases-
dc.subjectpediatric cancer-
dc.titleA Hematogenous Route for Medulloblastoma Leptomeningeal Metastases-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cell.2018.01.038-
dc.identifier.pmid29474906-
dc.identifier.pmcidPMC6346737-
dc.identifier.scopuseid_2-s2.0-85042368937-
dc.identifier.volume172-
dc.identifier.issue5-
dc.identifier.spage1050-
dc.identifier.epage1062.e14-
dc.identifier.eissn1097-4172-
dc.identifier.isiWOS:000425937100015-
dc.relation.erratumdoi:10.1016/j.cell.2018.05.033-
dc.relation.erratumeid:eid_2-s2.0-85047212452-

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