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Article: Intertumoral Heterogeneity within Medulloblastoma Subgroups

TitleIntertumoral Heterogeneity within Medulloblastoma Subgroups
Authors
Cavalli, Florence M.G.Remke, MarcRampasek, LadislavPeacock, JohnShih, David J.H.Luu, BettyGarzia, LiviaTorchia, JonathonNor, CarolinaMorrissy, A. SoranaAgnihotri, SameerThompson, Yuan YaoKuzan-Fischer, Claudia M.Farooq, HamzaIsaev, KerenDaniels, CraigCho, Byung KyuKim, Seung KiWang, Kyu ChangLee, Ji YeounGrajkowska, Wieslawa A.Perek-Polnik, MartaVasiljevic, AlexandreFaure-Conter, CecileJouvet, AnneGiannini, CaterinaNageswara Rao, Amulya A.Li, Kay Ka WaiNg, Ho KeungEberhart, Charles G.Pollack, Ian F.Hamilton, Ronald L.Gillespie, G. YanceyOlson, James M.Leary, SarahWeiss, William A.Lach, BoleslawChambless, Lola B.Thompson, Reid C.Cooper, Michael K.Vibhakar, RajeevHauser, Petervan Veelen, Marie Lise C.Kros, Johan M.French, Pim J.Ra, Young ShinKumabe, ToshihiroLópez-Aguilar, EnriqueZitterbart, KarelSterba, JaroslavFinocchiaro, GaetanoMassimino, MauraVan Meir, Erwin G.Osuka, SatoruShofuda, TomokoKlekner, AlmosZollo, MassimoLeonard, Jeffrey R.Rubin, Joshua B.Jabado, NadaAlbrecht, SteffenMora, JaumeVan Meter, Timothy E.Jung, ShinMoore, Andrew S.Hallahan, Andrew R.Chan, Jennifer A.Tirapelli, Daniela P.C.Carlotti, Carlos G.Fouladi, MaryamPimentel, JoséFaria, Claudia C.Saad, Ali G.Massimi, LucaLiau, Linda M.Wheeler, HelenNakamura, HideoElbabaa, Samer K.Perezpeña-Diazconti, MarioChico Ponce de León, FernandoRobinson, ShenandoahZapotocky, MichalLassaletta, AlvaroHuang, AnnieHawkins, Cynthia E.Tabori, UriBouffet, EricBartels, UteDirks, Peter B.Rutka, James T.Bader, Gary D.Reimand, JüriGoldenberg, AnnaRamaswamy, VijayTaylor, Michael D.
Keywordscopy number
gene expression
integrative clustering
medulloblastoma
methylation
subgroups
Issue Date2017
Citation
Cancer Cell, 2017, v. 31, n. 6, p. 737-754.e6 How to Cite?
AbstractWhile molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
Persistent Identifierhttp://hdl.handle.net/10722/313973
ISSN
2023 Impact Factor: 48.8
2023 SCImago Journal Rankings: 17.507
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCavalli, Florence M.G.-
dc.contributor.authorRemke, Marc-
dc.contributor.authorRampasek, Ladislav-
dc.contributor.authorPeacock, John-
dc.contributor.authorShih, David J.H.-
dc.contributor.authorLuu, Betty-
dc.contributor.authorGarzia, Livia-
dc.contributor.authorTorchia, Jonathon-
dc.contributor.authorNor, Carolina-
dc.contributor.authorMorrissy, A. Sorana-
dc.contributor.authorAgnihotri, Sameer-
dc.contributor.authorThompson, Yuan Yao-
dc.contributor.authorKuzan-Fischer, Claudia M.-
dc.contributor.authorFarooq, Hamza-
dc.contributor.authorIsaev, Keren-
dc.contributor.authorDaniels, Craig-
dc.contributor.authorCho, Byung Kyu-
dc.contributor.authorKim, Seung Ki-
dc.contributor.authorWang, Kyu Chang-
dc.contributor.authorLee, Ji Yeoun-
dc.contributor.authorGrajkowska, Wieslawa A.-
dc.contributor.authorPerek-Polnik, Marta-
dc.contributor.authorVasiljevic, Alexandre-
dc.contributor.authorFaure-Conter, Cecile-
dc.contributor.authorJouvet, Anne-
dc.contributor.authorGiannini, Caterina-
dc.contributor.authorNageswara Rao, Amulya A.-
dc.contributor.authorLi, Kay Ka Wai-
dc.contributor.authorNg, Ho Keung-
dc.contributor.authorEberhart, Charles G.-
dc.contributor.authorPollack, Ian F.-
dc.contributor.authorHamilton, Ronald L.-
dc.contributor.authorGillespie, G. Yancey-
dc.contributor.authorOlson, James M.-
dc.contributor.authorLeary, Sarah-
dc.contributor.authorWeiss, William A.-
dc.contributor.authorLach, Boleslaw-
dc.contributor.authorChambless, Lola B.-
dc.contributor.authorThompson, Reid C.-
dc.contributor.authorCooper, Michael K.-
dc.contributor.authorVibhakar, Rajeev-
dc.contributor.authorHauser, Peter-
dc.contributor.authorvan Veelen, Marie Lise C.-
dc.contributor.authorKros, Johan M.-
dc.contributor.authorFrench, Pim J.-
dc.contributor.authorRa, Young Shin-
dc.contributor.authorKumabe, Toshihiro-
dc.contributor.authorLópez-Aguilar, Enrique-
dc.contributor.authorZitterbart, Karel-
dc.contributor.authorSterba, Jaroslav-
dc.contributor.authorFinocchiaro, Gaetano-
dc.contributor.authorMassimino, Maura-
dc.contributor.authorVan Meir, Erwin G.-
dc.contributor.authorOsuka, Satoru-
dc.contributor.authorShofuda, Tomoko-
dc.contributor.authorKlekner, Almos-
dc.contributor.authorZollo, Massimo-
dc.contributor.authorLeonard, Jeffrey R.-
dc.contributor.authorRubin, Joshua B.-
dc.contributor.authorJabado, Nada-
dc.contributor.authorAlbrecht, Steffen-
dc.contributor.authorMora, Jaume-
dc.contributor.authorVan Meter, Timothy E.-
dc.contributor.authorJung, Shin-
dc.contributor.authorMoore, Andrew S.-
dc.contributor.authorHallahan, Andrew R.-
dc.contributor.authorChan, Jennifer A.-
dc.contributor.authorTirapelli, Daniela P.C.-
dc.contributor.authorCarlotti, Carlos G.-
dc.contributor.authorFouladi, Maryam-
dc.contributor.authorPimentel, José-
dc.contributor.authorFaria, Claudia C.-
dc.contributor.authorSaad, Ali G.-
dc.contributor.authorMassimi, Luca-
dc.contributor.authorLiau, Linda M.-
dc.contributor.authorWheeler, Helen-
dc.contributor.authorNakamura, Hideo-
dc.contributor.authorElbabaa, Samer K.-
dc.contributor.authorPerezpeña-Diazconti, Mario-
dc.contributor.authorChico Ponce de León, Fernando-
dc.contributor.authorRobinson, Shenandoah-
dc.contributor.authorZapotocky, Michal-
dc.contributor.authorLassaletta, Alvaro-
dc.contributor.authorHuang, Annie-
dc.contributor.authorHawkins, Cynthia E.-
dc.contributor.authorTabori, Uri-
dc.contributor.authorBouffet, Eric-
dc.contributor.authorBartels, Ute-
dc.contributor.authorDirks, Peter B.-
dc.contributor.authorRutka, James T.-
dc.contributor.authorBader, Gary D.-
dc.contributor.authorReimand, Jüri-
dc.contributor.authorGoldenberg, Anna-
dc.contributor.authorRamaswamy, Vijay-
dc.contributor.authorTaylor, Michael D.-
dc.date.accessioned2022-07-06T11:28:40Z-
dc.date.available2022-07-06T11:28:40Z-
dc.date.issued2017-
dc.identifier.citationCancer Cell, 2017, v. 31, n. 6, p. 737-754.e6-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10722/313973-
dc.description.abstractWhile molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.-
dc.languageeng-
dc.relation.ispartofCancer Cell-
dc.subjectcopy number-
dc.subjectgene expression-
dc.subjectintegrative clustering-
dc.subjectmedulloblastoma-
dc.subjectmethylation-
dc.subjectsubgroups-
dc.titleIntertumoral Heterogeneity within Medulloblastoma Subgroups-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ccell.2017.05.005-
dc.identifier.pmid28609654-
dc.identifier.pmcidPMC6163053-
dc.identifier.scopuseid_2-s2.0-85020687117-
dc.identifier.volume31-
dc.identifier.issue6-
dc.identifier.spage737-
dc.identifier.epage754.e6-
dc.identifier.eissn1878-3686-
dc.identifier.isiWOS:000403074800005-

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