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Article: Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

TitleGenome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Authors
Issue Date2012
Citation
Cell, 2012, v. 148, n. 1-2, p. 59-71 How to Cite?
AbstractGenomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/313950
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRausch, Tobias-
dc.contributor.authorJones, David T.W.-
dc.contributor.authorZapatka, Marc-
dc.contributor.authorStütz, Adrian M.-
dc.contributor.authorZichner, Thomas-
dc.contributor.authorWeischenfeldt, Joachim-
dc.contributor.authorJäger, Natalie-
dc.contributor.authorRemke, Marc-
dc.contributor.authorShih, David-
dc.contributor.authorNorthcott, Paul A.-
dc.contributor.authorPfaff, Elke-
dc.contributor.authorTica, Jelena-
dc.contributor.authorWang, Qi-
dc.contributor.authorMassimi, Luca-
dc.contributor.authorWitt, Hendrik-
dc.contributor.authorBender, Sebastian-
dc.contributor.authorPleier, Sabrina-
dc.contributor.authorCin, Huriye-
dc.contributor.authorHawkins, Cynthia-
dc.contributor.authorBeck, Christian-
dc.contributor.authorVon Deimling, Andreas-
dc.contributor.authorHans, Volkmar-
dc.contributor.authorBrors, Benedikt-
dc.contributor.authorEils, Roland-
dc.contributor.authorScheurlen, Wolfram-
dc.contributor.authorBlake, Jonathon-
dc.contributor.authorBenes, Vladimir-
dc.contributor.authorKulozik, Andreas E.-
dc.contributor.authorWitt, Olaf-
dc.contributor.authorMartin, Dianna-
dc.contributor.authorZhang, Cindy-
dc.contributor.authorPorat, Rinnat-
dc.contributor.authorMerino, Diana M.-
dc.contributor.authorWasserman, Jonathan-
dc.contributor.authorJabado, Nada-
dc.contributor.authorFontebasso, Adam-
dc.contributor.authorBullinger, Lars-
dc.contributor.authorRücker, Frank G.-
dc.contributor.authorDöhner, Konstanze-
dc.contributor.authorDöhner, Hartmut-
dc.contributor.authorKoster, Jan-
dc.contributor.authorMolenaar, Jan J.-
dc.contributor.authorVersteeg, Rogier-
dc.contributor.authorKool, Marcel-
dc.contributor.authorTabori, Uri-
dc.contributor.authorMalkin, David-
dc.contributor.authorKorshunov, Andrey-
dc.contributor.authorTaylor, Michael D.-
dc.contributor.authorLichter, Peter-
dc.contributor.authorPfister, Stefan M.-
dc.contributor.authorKorbel, Jan O.-
dc.date.accessioned2022-07-06T11:28:34Z-
dc.date.available2022-07-06T11:28:34Z-
dc.date.issued2012-
dc.identifier.citationCell, 2012, v. 148, n. 1-2, p. 59-71-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/313950-
dc.description.abstractGenomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 status with microarray and deep sequencing-based DNA rearrangement data in additional patients reveals a striking association between TP53 mutation and chromothripsis in SHH-MBs. Analysis of additional tumor entities substantiates a link between TP53 mutation and chromothripsis, and indicates a context-specific role for p53 in catastrophic DNA rearrangements. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings connect p53 status and chromothripsis in specific tumor types, providing a genetic basis for understanding particularly aggressive subtypes of cancer. © 2012 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofCell-
dc.titleGenome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cell.2011.12.013-
dc.identifier.pmid22265402-
dc.identifier.pmcidPMC3332216-
dc.identifier.scopuseid_2-s2.0-84862907577-
dc.identifier.volume148-
dc.identifier.issue1-2-
dc.identifier.spage59-
dc.identifier.epage71-
dc.identifier.eissn1097-4172-
dc.identifier.isiWOS:000299540700014-

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