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Article: Age-dependent genetic architecture across ontogeny of body size in sticklebacks
Title | Age-dependent genetic architecture across ontogeny of body size in sticklebacks |
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Authors | |
Keywords | QTL mapping genetic architecture genetic correlation heritability ontogeny |
Issue Date | 2022 |
Publisher | The Royal Society Publishing. The Journal's web site is located at http://rspb.royalsocietypublishing.org/ |
Citation | Proceedings of the Royal Society B: Biological Sciences, 2022, v. 289 n. 1975, article no. 20220352 How to Cite? |
Abstract | Heritable variation in traits under natural selection is a prerequisite for evolutionary response. While it is recognized that trait heritability may vary spatially and temporally depending on which environmental conditions traits are expressed under, less is known about the possibility that genetic variance contributing to the expected selection response in a given trait may vary at different stages of ontogeny. Specifically, whether different loci underlie the expression of a trait throughout development and thus providing an additional source of variation for selection to act on in the wild, is unclear. Here we show that body size, an important life-history trait, is heritable throughout ontogeny in the nine-spined stickleback (Pungitius pungitius). Nevertheless, both analyses of quantitative trait loci and genetic
correlations across ages show that different chromosomes/loci contribute to this heritability in different ontogenic time-points. This suggests that body size can respond to selection at different stages of ontogeny but that this response is determined by different loci at different points of development. Hence, our study provides important results regarding our understanding of the genetics of ontogeny and opens an interesting avenue of research for studying age-specific genetic architecture as a source of non-parallel evolution. |
Persistent Identifier | http://hdl.handle.net/10722/313299 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.692 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fraimout, A | - |
dc.contributor.author | Zitong, Z | - |
dc.contributor.author | Sillanpää, MJ | - |
dc.contributor.author | Merilae, JKK | - |
dc.date.accessioned | 2022-06-06T05:49:03Z | - |
dc.date.available | 2022-06-06T05:49:03Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Proceedings of the Royal Society B: Biological Sciences, 2022, v. 289 n. 1975, article no. 20220352 | - |
dc.identifier.issn | 0962-8452 | - |
dc.identifier.uri | http://hdl.handle.net/10722/313299 | - |
dc.description.abstract | Heritable variation in traits under natural selection is a prerequisite for evolutionary response. While it is recognized that trait heritability may vary spatially and temporally depending on which environmental conditions traits are expressed under, less is known about the possibility that genetic variance contributing to the expected selection response in a given trait may vary at different stages of ontogeny. Specifically, whether different loci underlie the expression of a trait throughout development and thus providing an additional source of variation for selection to act on in the wild, is unclear. Here we show that body size, an important life-history trait, is heritable throughout ontogeny in the nine-spined stickleback (Pungitius pungitius). Nevertheless, both analyses of quantitative trait loci and genetic correlations across ages show that different chromosomes/loci contribute to this heritability in different ontogenic time-points. This suggests that body size can respond to selection at different stages of ontogeny but that this response is determined by different loci at different points of development. Hence, our study provides important results regarding our understanding of the genetics of ontogeny and opens an interesting avenue of research for studying age-specific genetic architecture as a source of non-parallel evolution. | - |
dc.language | eng | - |
dc.publisher | The Royal Society Publishing. The Journal's web site is located at http://rspb.royalsocietypublishing.org/ | - |
dc.relation.ispartof | Proceedings of the Royal Society B: Biological Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | QTL mapping | - |
dc.subject | genetic architecture | - |
dc.subject | genetic correlation | - |
dc.subject | heritability | - |
dc.subject | ontogeny | - |
dc.title | Age-dependent genetic architecture across ontogeny of body size in sticklebacks | - |
dc.type | Article | - |
dc.identifier.email | Merilae, JKK: merila@hku.hk | - |
dc.identifier.authority | Merilae, JKK=rp02753 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1098/rspb.2022.0352 | - |
dc.identifier.hkuros | 333270 | - |
dc.identifier.volume | 289 | - |
dc.identifier.issue | 1975 | - |
dc.identifier.spage | article no. 20220352 | - |
dc.identifier.epage | article no. 20220352 | - |
dc.identifier.isi | WOS:000797858800013 | - |
dc.publisher.place | United Kingdom | - |