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- Publisher Website: 10.1039/d0cs00031k
- Scopus: eid_2-s2.0-85118598948
- PMID: 34533144
- WOS: WOS:000696592900001
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Article: Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles
Title | Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles |
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Authors | |
Issue Date | 2021 |
Citation | Chemical Society Reviews, 2021, v. 50, n. 21, p. 12037-12069 How to Cite? |
Abstract | Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications. Bismuth-based compounds are used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, gastric ulcers and H. pylori infections. Recently, its medicinal application was further extended to potential treatments of viral infection, multidrug resistant microbial infections, cancer and also imaging, drug delivery and biosensing. In this review we have highlighted the unique chemistry and biological chemistry of bismuth-209 as a prelude to sections covering the unique antibacterial activity of bismuth including a description of research undertaken to date to elucidate key molecular mechanisms of action against H. pylori, the development of novel compounds to treat infection from microbes beyond H. pylori and the significant role bismuth compounds can play as resistance breakers. Furthermore we have provided an account of the potential therapeutic application of bismuth-213 in targeted alpha therapy as well as a summary of the biomedical applications of bismuth-based nanoparticles and composites. Ultimately this review aims to provide the state of the art, highlight the untapped biomedical potential of bismuth and encourage original contributions to this exciting and important field. |
Persistent Identifier | http://hdl.handle.net/10722/313033 |
ISSN | 2023 Impact Factor: 40.4 2023 SCImago Journal Rankings: 12.511 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Griffith, Darren M. | - |
dc.contributor.author | Li, Hongyan | - |
dc.contributor.author | Werrett, Melissa V. | - |
dc.contributor.author | Andrews, Philip C. | - |
dc.contributor.author | Sun, Hongzhe | - |
dc.date.accessioned | 2022-05-26T07:00:08Z | - |
dc.date.available | 2022-05-26T07:00:08Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Chemical Society Reviews, 2021, v. 50, n. 21, p. 12037-12069 | - |
dc.identifier.issn | 0306-0012 | - |
dc.identifier.uri | http://hdl.handle.net/10722/313033 | - |
dc.description.abstract | Bismuth as a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications. Bismuth-based compounds are used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, gastric ulcers and H. pylori infections. Recently, its medicinal application was further extended to potential treatments of viral infection, multidrug resistant microbial infections, cancer and also imaging, drug delivery and biosensing. In this review we have highlighted the unique chemistry and biological chemistry of bismuth-209 as a prelude to sections covering the unique antibacterial activity of bismuth including a description of research undertaken to date to elucidate key molecular mechanisms of action against H. pylori, the development of novel compounds to treat infection from microbes beyond H. pylori and the significant role bismuth compounds can play as resistance breakers. Furthermore we have provided an account of the potential therapeutic application of bismuth-213 in targeted alpha therapy as well as a summary of the biomedical applications of bismuth-based nanoparticles and composites. Ultimately this review aims to provide the state of the art, highlight the untapped biomedical potential of bismuth and encourage original contributions to this exciting and important field. | - |
dc.language | eng | - |
dc.relation.ispartof | Chemical Society Reviews | - |
dc.title | Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/d0cs00031k | - |
dc.identifier.pmid | 34533144 | - |
dc.identifier.scopus | eid_2-s2.0-85118598948 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | 21 | - |
dc.identifier.spage | 12037 | - |
dc.identifier.epage | 12069 | - |
dc.identifier.eissn | 1460-4744 | - |
dc.identifier.isi | WOS:000696592900001 | - |