File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study

TitleRisk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study
Authors
Keywordshemagglutination inhibition antibody
influenza infection attack rate
influenza-like illness
neuraminidase inhibition antibody
seroepidemiologic cohort
Issue Date2019
Citation
Journal of Infectious Diseases, 2019, v. 219, n. 3, p. 347-357 How to Cite?
AbstractBackground. Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of antihemagglutinin antibody responses have been described previously, studies examining both antihemagglutinin and antineuraminidase antibodies are lacking. Methods. In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI). Results. Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%.38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR.confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001). Conclusions. Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates.
Persistent Identifierhttp://hdl.handle.net/10722/312045
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 2.387
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, Q. Sue-
dc.contributor.authorBandaranayake, Don-
dc.contributor.authorWood, Tim-
dc.contributor.authorNewbern, E. Claire-
dc.contributor.authorSeeds, Ruth-
dc.contributor.authorRalston, Jacqui-
dc.contributor.authorWaite, Ben-
dc.contributor.authorBissielo, Ange-
dc.contributor.authorPrasad, Namrata-
dc.contributor.authorTodd, Angela-
dc.contributor.authorJelley, Lauren-
dc.contributor.authorGunn, Wendy-
dc.contributor.authorMcNicholas, Anne-
dc.contributor.authorMetz, Thomas-
dc.contributor.authorLawrence, Shirley-
dc.contributor.authorCollis, Emma-
dc.contributor.authorRetter, Amanda-
dc.contributor.authorWong, Sook San-
dc.contributor.authorWebby, Richard-
dc.contributor.authorBocacao, Judy-
dc.contributor.authorHaubrock, Jennifer-
dc.contributor.authorMackereth, Graham-
dc.contributor.authorTurner, Nikki-
dc.contributor.authorMcArdle, Barbara-
dc.contributor.authorCameron, John-
dc.contributor.authorReynolds, Edwin G.-
dc.contributor.authorBaker, Michael G.-
dc.contributor.authorGrant, Cameron C.-
dc.contributor.authorMcArthur, Colin-
dc.contributor.authorRoberts, Sally-
dc.contributor.authorTrenholme, Adrian-
dc.contributor.authorWong, Conroy-
dc.contributor.authorTaylor, Susan-
dc.contributor.authorThomas, Paul-
dc.contributor.authorDuque, Jazmin-
dc.contributor.authorGross, Diane-
dc.contributor.authorThompson, Mark G.-
dc.contributor.authorWiddowson, Marc Alain-
dc.date.accessioned2022-04-06T04:32:03Z-
dc.date.available2022-04-06T04:32:03Z-
dc.date.issued2019-
dc.identifier.citationJournal of Infectious Diseases, 2019, v. 219, n. 3, p. 347-357-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/312045-
dc.description.abstractBackground. Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of antihemagglutinin antibody responses have been described previously, studies examining both antihemagglutinin and antineuraminidase antibodies are lacking. Methods. In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI). Results. Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%.38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR.confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001). Conclusions. Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates.-
dc.languageeng-
dc.relation.ispartofJournal of Infectious Diseases-
dc.subjecthemagglutination inhibition antibody-
dc.subjectinfluenza infection attack rate-
dc.subjectinfluenza-like illness-
dc.subjectneuraminidase inhibition antibody-
dc.subjectseroepidemiologic cohort-
dc.titleRisk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jiy443-
dc.identifier.pmid30016464-
dc.identifier.scopuseid_2-s2.0-85059796943-
dc.identifier.volume219-
dc.identifier.issue3-
dc.identifier.spage347-
dc.identifier.epage357-
dc.identifier.eissn1537-6613-
dc.identifier.isiWOS:000462598400003-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats