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- Publisher Website: 10.1080/19490976.2020.1830699
- Scopus: eid_2-s2.0-85098645942
- PMID: 33382948
- WOS: WOS:000623328300001
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Article: Exposure to soil environments during earlier life stages is distinguishable in the gut microbiome of adult mice
Title | Exposure to soil environments during earlier life stages is distinguishable in the gut microbiome of adult mice |
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Authors | |
Keywords | Germ free mice Gut microbiota Metagenome Migrations Soil environment exposure |
Issue Date | 2021 |
Citation | Gut Microbes, 2021, v. 13, n. 1, article no. 1830699 How to Cite? |
Abstract | Environmental exposure during earlier life stages can govern the assembly and development of gut microbiota, yet it is insufficiently understood. In this study, ex-germ-free mice were cohoused with distinct soil-microbiota (from desert, steppe, and forest) beddings within 60 days after birth and subsequently transferred to new soil beddings from 60 to 90th day. Using metagenomic shotgun sequencing, firstly, we found soil microbes from natural environments (birthplace) greatly influenced the gut community assembly in the housing experiment. About 27% microbial species and 12% functional components that associated with birthplaces at Day 60 were still discriminatory of birthplaces after transferring mice to new environments. Moreover, prior soil-exposure types are associated with the magnitude of temporal microbiome change due to environmental shifts. The appropriate soil-exposure (e.g., steppe) might help mice gut microbiome adapt to changing environments or host development. Our study demonstrated the continuous soil-exposure history earlier is associated with the gut microbiome individuality and development later. |
Persistent Identifier | http://hdl.handle.net/10722/311501 |
ISSN | 2023 Impact Factor: 12.2 2023 SCImago Journal Rankings: 3.075 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Wenjun | - |
dc.contributor.author | Sun, Zheng | - |
dc.contributor.author | Ma, Chen | - |
dc.contributor.author | Zhang, Jiachao | - |
dc.contributor.author | Ma, Chen Chen | - |
dc.contributor.author | Zhao, Yinqi | - |
dc.contributor.author | Wei, Hong | - |
dc.contributor.author | Huang, Shi | - |
dc.contributor.author | Zhang, Heping | - |
dc.date.accessioned | 2022-03-22T11:54:05Z | - |
dc.date.available | 2022-03-22T11:54:05Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Gut Microbes, 2021, v. 13, n. 1, article no. 1830699 | - |
dc.identifier.issn | 1949-0976 | - |
dc.identifier.uri | http://hdl.handle.net/10722/311501 | - |
dc.description.abstract | Environmental exposure during earlier life stages can govern the assembly and development of gut microbiota, yet it is insufficiently understood. In this study, ex-germ-free mice were cohoused with distinct soil-microbiota (from desert, steppe, and forest) beddings within 60 days after birth and subsequently transferred to new soil beddings from 60 to 90th day. Using metagenomic shotgun sequencing, firstly, we found soil microbes from natural environments (birthplace) greatly influenced the gut community assembly in the housing experiment. About 27% microbial species and 12% functional components that associated with birthplaces at Day 60 were still discriminatory of birthplaces after transferring mice to new environments. Moreover, prior soil-exposure types are associated with the magnitude of temporal microbiome change due to environmental shifts. The appropriate soil-exposure (e.g., steppe) might help mice gut microbiome adapt to changing environments or host development. Our study demonstrated the continuous soil-exposure history earlier is associated with the gut microbiome individuality and development later. | - |
dc.language | eng | - |
dc.relation.ispartof | Gut Microbes | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Germ free mice | - |
dc.subject | Gut microbiota | - |
dc.subject | Metagenome | - |
dc.subject | Migrations | - |
dc.subject | Soil environment exposure | - |
dc.title | Exposure to soil environments during earlier life stages is distinguishable in the gut microbiome of adult mice | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1080/19490976.2020.1830699 | - |
dc.identifier.pmid | 33382948 | - |
dc.identifier.pmcid | PMC7781656 | - |
dc.identifier.scopus | eid_2-s2.0-85098645942 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 1830699 | - |
dc.identifier.epage | article no. 1830699 | - |
dc.identifier.eissn | 1949-0984 | - |
dc.identifier.isi | WOS:000623328300001 | - |