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Article: Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis

TitleCow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis
Authors
KeywordsFecal microbiota transplantation
Germ-free mice
Intestinal microbiota
Mastitis
Probiotics
Issue Date2018
Citation
Microbiome, 2018, v. 6, n. 1, article no. 200 How to Cite?
AbstractBackground: Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis. Results: Fecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal microbiota to a state that is functionally distinct from either healthy or diseased microbiota yet structurally similar to the latter. Despite conservation in mastitis symptoms, diseased cows and mice shared few mastitis-associated bacterial organismal or functional markers, suggesting striking divergence in mastitis-associated intestinal microbiota among lactating mammals. Moreover, an "amplification effect" of disease-health distinction in both microbiota structure and function was apparent during the cow-to-mouse FMT. Conclusions: Hence, dysbiosis of intestinal microbiota may be one cause of mastitis, and probiotics that restore intestinal microbiota function are an effective and safe strategy to treat mastitis.
Persistent Identifierhttp://hdl.handle.net/10722/311453
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Chen-
dc.contributor.authorSun, Zheng-
dc.contributor.authorZeng, Benhua-
dc.contributor.authorHuang, Shi-
dc.contributor.authorZhao, Jie-
dc.contributor.authorZhang, Yong-
dc.contributor.authorSu, Xiaoquan-
dc.contributor.authorXu, Jian-
dc.contributor.authorWei, Hong-
dc.contributor.authorZhang, Heping-
dc.date.accessioned2022-03-22T11:53:58Z-
dc.date.available2022-03-22T11:53:58Z-
dc.date.issued2018-
dc.identifier.citationMicrobiome, 2018, v. 6, n. 1, article no. 200-
dc.identifier.urihttp://hdl.handle.net/10722/311453-
dc.description.abstractBackground: Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis. Results: Fecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal microbiota to a state that is functionally distinct from either healthy or diseased microbiota yet structurally similar to the latter. Despite conservation in mastitis symptoms, diseased cows and mice shared few mastitis-associated bacterial organismal or functional markers, suggesting striking divergence in mastitis-associated intestinal microbiota among lactating mammals. Moreover, an "amplification effect" of disease-health distinction in both microbiota structure and function was apparent during the cow-to-mouse FMT. Conclusions: Hence, dysbiosis of intestinal microbiota may be one cause of mastitis, and probiotics that restore intestinal microbiota function are an effective and safe strategy to treat mastitis.-
dc.languageeng-
dc.relation.ispartofMicrobiome-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFecal microbiota transplantation-
dc.subjectGerm-free mice-
dc.subjectIntestinal microbiota-
dc.subjectMastitis-
dc.subjectProbiotics-
dc.titleCow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s40168-018-0578-1-
dc.identifier.pmid30409169-
dc.identifier.pmcidPMC6225715-
dc.identifier.scopuseid_2-s2.0-85056262438-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spagearticle no. 200-
dc.identifier.epagearticle no. 200-
dc.identifier.eissn2049-2618-
dc.identifier.isiWOS:000449968500002-

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