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Article: Dengue virus serotype distribution based on serological evidence in pediatric urban population in Indonesia

TitleDengue virus serotype distribution based on serological evidence in pediatric urban population in Indonesia
Authors
Issue Date2018
Citation
PLoS Neglected Tropical Diseases, 2018, v. 12, n. 6, article no. e0006616 How to Cite?
AbstractBackground: Dengue is a febrile illness transmitted by mosquitoes, causing disease across the tropical and sub-tropical world. Antibody prevalence data and serotype distributions describe population-level risk and inform public health decision-making. Methodology/Principal findings: In this cross-sectional study we used data from a pediatric dengue seroprevalence study to describe historical dengue serotype circulation, according to age and geographic location. A sub-sample of 780 dengue IgG-positive sera, collected from 30 sites across urban Indonesia in 2014, were tested by the plaque reduction neutralization test (PRNT) to measure the prevalence and concentration of serotype-specific neutralizing antibodies according to subject age and geography. PRNT results were obtained from 776 subjects with mean age of 9.6 years. 765 (98.6%) neutralized one or more dengue serotype at a threshold of >10 (1/dil). Multitypic profiles were observed in 50.9% of the samples; a proportion which increased to 63.1% in subjects aged 15–18 years. Amongst monotypic samples, the highest proportion was reactive against DENV-2, followed by DENV-1, and DENV-3, with some variation across the country. DENV-4 was the least common serotype. The highest anti-dengue antibody titers were recorded against DENV-2, and increased with age to a geometric mean of 516.5 [1/dil] in the oldest age group. Conclusions/Significance: We found that all four dengue serotypes have been widely circulating in most of urban Indonesia, and more than half of children had already been exposed to >1 dengue serotype, demonstrating intense transmission often associated with more severe clinical episodes. These data will help inform policymakers and highlight the importance of dengue surveillance, prevention and control.
Persistent Identifierhttp://hdl.handle.net/10722/311446
ISSN
2011 Impact Factor: 4.716
2023 SCImago Journal Rankings: 1.258
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSasmono, R. Tedjo-
dc.contributor.authorTaurel, Anne Frieda-
dc.contributor.authorPrayitno, Ari-
dc.contributor.authorSitompul, Hermin-
dc.contributor.authorYohan, Benediktus-
dc.contributor.authorHayati, Rahma F.-
dc.contributor.authorBouckenooghe, Alain-
dc.contributor.authorHadinegoro, Sri Rezeki-
dc.contributor.authorNealon, Joshua-
dc.date.accessioned2022-03-22T11:53:57Z-
dc.date.available2022-03-22T11:53:57Z-
dc.date.issued2018-
dc.identifier.citationPLoS Neglected Tropical Diseases, 2018, v. 12, n. 6, article no. e0006616-
dc.identifier.issn1935-2727-
dc.identifier.urihttp://hdl.handle.net/10722/311446-
dc.description.abstractBackground: Dengue is a febrile illness transmitted by mosquitoes, causing disease across the tropical and sub-tropical world. Antibody prevalence data and serotype distributions describe population-level risk and inform public health decision-making. Methodology/Principal findings: In this cross-sectional study we used data from a pediatric dengue seroprevalence study to describe historical dengue serotype circulation, according to age and geographic location. A sub-sample of 780 dengue IgG-positive sera, collected from 30 sites across urban Indonesia in 2014, were tested by the plaque reduction neutralization test (PRNT) to measure the prevalence and concentration of serotype-specific neutralizing antibodies according to subject age and geography. PRNT results were obtained from 776 subjects with mean age of 9.6 years. 765 (98.6%) neutralized one or more dengue serotype at a threshold of >10 (1/dil). Multitypic profiles were observed in 50.9% of the samples; a proportion which increased to 63.1% in subjects aged 15–18 years. Amongst monotypic samples, the highest proportion was reactive against DENV-2, followed by DENV-1, and DENV-3, with some variation across the country. DENV-4 was the least common serotype. The highest anti-dengue antibody titers were recorded against DENV-2, and increased with age to a geometric mean of 516.5 [1/dil] in the oldest age group. Conclusions/Significance: We found that all four dengue serotypes have been widely circulating in most of urban Indonesia, and more than half of children had already been exposed to >1 dengue serotype, demonstrating intense transmission often associated with more severe clinical episodes. These data will help inform policymakers and highlight the importance of dengue surveillance, prevention and control.-
dc.languageeng-
dc.relation.ispartofPLoS Neglected Tropical Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleDengue virus serotype distribution based on serological evidence in pediatric urban population in Indonesia-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pntd.0006616-
dc.identifier.pmid29953438-
dc.identifier.pmcidPMC6040755-
dc.identifier.scopuseid_2-s2.0-85049359871-
dc.identifier.volume12-
dc.identifier.issue6-
dc.identifier.spagearticle no. e0006616-
dc.identifier.epagearticle no. e0006616-
dc.identifier.eissn1935-2735-
dc.identifier.isiWOS:000437442000064-

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